666 results
To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low cTML (<300 nonsynonymous mutations) and either actionable mutation, inactivating STK11 or KEAP1…
To investigate the effect of a daily sachet of probiotics for 12 weeks vs placebo on vitamin K status in renal transplant recipients.
Primary objective: To determine the characteristics of language, speech and motor functions in MCI due to AD, mild AD and moderate AD Secondary objective: To explore the association between language, speech and motor functions in MCI due to AD and…
Primary Endpoint: Feasibility of including patients in the study, randomization and delivery of the intervention. To assess the primary endpoint, we will examine the probability that: (1) a screened patient is eligible; (2) an eligible patient…
To establish the performance of the idi-CGM system among persons with DM.
To determine prospectively the correlation between in vitro patient-derived organoid response and progression-free survival.
We aim to define components which are critical for lysosomal homeostasis and are affected in CLN3 disease. To this end we will perform multi-omics analysis of lysosomes isolated from fresh peripheral white blood mononuclear cells (PBMCs) of…
The primary objective of this study is to determine the safety and feasibility of turbine-based insufflation, measured in terms of occurrence of adverse device effects and serious adverse device effects. The secondary objectives are to determine the…
Primary objectives:- To assess the differences in resting state EEG frequency spectrum analysis between patients with neurodegenerative and patients with non-neurological causes of MCI.* Power in microvolts squared of resting stage EEG for different…
2. OBJECTIVESThe overarching goal of this proposal is to examine the feasibility and effectiveness of mobile-based screening for MDD. We combine validated screening and interventions for MDD with innovative outreach methods to maximize impact.…
To determine whether guided growth of the proximal femur decreases the risk of further hip migration and need for further surgery in cerebral palsy patients.
The main objective is to investigate whether the additional use of IVUS leads to an increase in net lumen gain (NLG) when compared with standard angiography-guided endovascular treatment as measured during control IVUS after six weeks. Secondary…
To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) in patients with ANOCA on the change in the summary score of the Seattle Angina Questionnaire (SS SAQ) after 1 month treatment with TENS, compared to baseline.
To test whether tACS in a theta frequency enhances extinction of physiological stress responses to exposure to anxiety- or trauma-related stimuli or memories. Secondarily, to examine the influence of baseline neuroendocrinological response, baseline…
To investigate the fluctuation patterns of different pulmonary parameters in patients with severe asthma, before and after starting a treatment with biologics, using daily measurements with the Respicorder device.
This study examines a the role of four key ultra-high-risk criteria for personality disorders: interpersonal trauma, personality functioning, quality of social support system and subclinical features of borderline personality disorder. For two of…
This study aims to evaluate the Corsano Cardiowatch 287-2 for heart rate, heart rate variability (RR intervals), oxygen saturation, respiratory rate, and blood pressure during strenuous activities such as High-Intensity Interval Training (HIIT).…
Demonstrate that the self-expandable Allegra TAVI system provides lower mean gradient assessed by TTE compared to balloon-expandable valve systems in a population of all women patients with symptomatic severe aortic valve stenosis.
The aim of this study is to evaluate the validity of various algorithms for gait bout detection and spatiotemporal measures with a 3-IMU based sensor set worn on the feet and lower back. If this algorithm can be validated, it can be used to obtain…
We aim to investigate language production and verbal episodic memory performance, as well as the respective associated neural (co-)organisation of the two systems observed post-surgery in people with left temporal epilepsy in comparison to healthy…