No registrations found.
ID
Source
Brief title
Health condition
obesity, atrial fibrillation, adipose tissue, electrophysiology, metabolism, epicardial, paracardial, CT-scan
Sponsors and support
Intervention
Outcome measures
Primary outcome
multiple outcomes to identify intra-individual changes of clinical and biochemical markers of AT characteristics upon drastic weightloss:
- AT mass, distribution and ratios (EAT, PAT,VAT)
- Circulating AT derived protein biomarkers, including: inflammatory markers
- Circulating AT derived miRNAs
- Locally AT derived protein biomarkers, extracted from VAT. Markers similar to those in circulation.
- Locally AT derived miRNAs extracted from VAT.
- Anthropometric measurements: height, weight, BMI, waist-circumference, hip-waist ratio.
- Occurrence/absence of AF by an approved 7 days rhythm monitoring system.
- International Physical Activity Questionnaire.
Secondary outcome
-
Background summary
Obese patients experience more AF occurrences and recurrences compared to patients with a healthy BMI. Clinically, weight loss in obese patients with AF increases AF freedom in a dose-dependent manner, resulting in 50% absence of AF in patients losing >10% bodyweight. These results present a significant relationship between obesity and AF. However, details on the mechanisms underlying this relationship and on reversible pathological factors remain to be discovered.
Therefore, we designed a study in which obesity along with adipose tissue (AT) characteristics are studied upon drastic weight loss. Currently, how drastic weight loss reduces the pro-arrhythmic effect is unknown. AT characteristics before and after weight loss will be compared to AT characteristics from patients with and without AF, obtained from other studies. In this study we aim at investigating the alterations in cardiac AT mass, AT activity and anthropometrics that occur upon drastic weight loss, and at understanding how certain of these fat characteristics predispose to AF.
Study objective
Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we hypothesize that AT functioning may be responsible for AF occurence.
Study design
Pre-operative: CT scan, blood samples, holter, questioannaire, ECG
Operation: adipose tissue biopsies
Follow-up 6 months: holter, blood samples
Follow-up 12 months: CT scan, blood samples, holter, questioannaire, ECG
Intervention
1. Adipose tissue biopsies during bariatric surgery
2. Blood extraction pre operative and during follow-up
3. CT scan pre-operative and during follow-up
Inclusion criteria
- Patient undergoing bariatric surgery (BMI above 35)
- Age above 40
Exclusion criteria
- Taking 2 or more antihypertensiva
- Taking metformine for diabetes
- Heart diseases, for example myocardinfarct in past
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6989 |
| NTR-old | NTR7178 |
| Other | : Protocol ID: NL62056.018.17 |