No registrations found.
ID
Source
Brief title
Health condition
Measurements in 48 healthy subjects aged 20 to 35 years (24 subjects) and 55 to 70 years (24 subjects).
Sponsors and support
Hanzeplein 1
Postbus 30.001
9700 RB Groningen
The Netherlands
Tel: (+31)050-3612510
Fax: (+31)050-3611709
AMO (advanced medical optics) Groningen B.V.
Van Swietenlaan 5
9728 NX Groningen
Tel: (+31)050-5296600
Fax: (+31)050-5267860
Intervention
Outcome measures
Primary outcome
Selection of the contrast sensitivity test which predicts the spherical aberration most reliably.
Secondary outcome
1. Spherical aberration as function of age;
2. RMS as function of age;
3. Contrast sensitivity as function of age;
4. Influence of defocus on contrast sensitivity.
Background summary
The relation between contrast sensitivity and spherical aberration and other higher order aberrations (RMS) will be studied in young and elderly subjects without ocular pathology. Contrast sensitivity will be assessed with the use of eight different contrast sensitivity tests at optimal focus and at positive and negative defocus. These results will be related to the higher order aberrations of the eyes.
Study objective
Higher order aberrations, like spherical aberration, decreases visual performance.
Study design
N/A
Intervention
Best corrected visual acuity was determined with an ETDRS chart and the spherical aberration (SA) was measured with a wavefront analyzer (WASCA version 1.26.3, Asclepion Meditec, Jena, Germany).
The contrast sensitivity is measured with two computerized tests:
1. One with vertical sine-wave gratings (1.5-12 cpd) generated on a CRT (Cambridge Research Systems, Rochester, UK; Von Bekesy tracking method);
2. The Holladay sine-wave (1.5 -18 cpd) modulated circular lines (HACSS) (M&S Technologies, Skokie, Illinois, USA), and with six contrast sensitivity chart tests:
1. Pelli Robson contrast sensitivity test;
2. low contrast ETDRS-like optotype chart 2.5%;
3. Low contrast ETDRS-like optotype chart 10%;
4. Edge contrast sensitivity test: GECKO;
5. Edge contrast sensitivity test: GECKO-100;
6. Vector Vision. Contrast sensitivity is measured in mesopic (3 cd/m2) and photopic (160 cd/m2) conditions, using only the dominant eye.
Tests were performed at optimal refractive state of the eye and at a variety of defocus situations(-2D to 2D).
Groningen (UMCG), Department Ophtalmology,
P.O. box 30.001
K.W. Gaalen, van
Hanzeplein 1
Groningen 9700 RB
The Netherlands
+31 (0)50 3619692
k.van.gaalen@ohk.umcg.nl
Groningen (UMCG), Department Ophtalmology,
P.O. box 30.001
K.W. Gaalen, van
Hanzeplein 1
Groningen 9700 RB
The Netherlands
+31 (0)50 3619692
k.van.gaalen@ohk.umcg.nl
Inclusion criteria
No ocular pathology.
Exclusion criteria
1. Refractive correction larger than +/- 2 D;
2. Cylindrical correction larger than 1.5 D;
3. Cylindrical axis more then 20ยบ from the horizontal or vertical axis.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
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In other registers
Register | ID |
---|---|
NTR-new | NL799 |
NTR-old | NTR812 |
Other | : 1 |
ISRCTN | ISRCTN66724598 |