No registrations found.
ID
Source
Brief title
Health condition
Observational study.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Percentage of patients reaching DAS28<2.6.
Secondary outcome
1. Radiographic changes;
2. Percentage of patients staying in remission;
3. Percentage of patients staying in remission after discontinuation of anti-YNF medication.
Background summary
Patients with recent onset RA are treated according to a tight step up medication scheme. Aim of treatment is to reach clinical remission of the disease as soon as possible, DAS 28 < 2.6. Introduction of anti-TNF medication is possible after the use of 2 DMARDs, according to the present Dutch regulations for the use of anti-TNF in clinical practice. If remission is reached with the use of anti-TNF and the disease stays in remission for 6 months, de anti-TNF dose will reduced and in the case of persisting remission be stopped. Radiographic damge and disease activity will be monitored regularly.
Study objective
Early and aggressive treatment of rheumatoid arthritis according to a strict treatment protocol results in a 70% remission of the disease within 2 years.
Study design
N/A
Intervention
Tight control of disease activity by a strict treatment scheme and strictly defined decision moments for treatment changes.
Inclusion criteria
1. RA according to ACR1987 criteria;
2. diagnosis RA <3 months;
3. age >18;
4. no prior DMARD use;
5. DAS 28 > 3.2 and/or erosions.
Exclusion criteria
Pregnancy/pregnancy wish.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL534 |
| NTR-old | NTR578 |
| Other | : N/A |
| ISRCTN | Incomplete info for ISRCTN |