No registrations found.
ID
Source
Brief title
Health condition
Hypertension
High blood pressure
Proteins
Hoge bloeddruk
Hypertensie
Eiwitten
Sponsors and support
Intervention
Outcome measures
Primary outcome
Acute TPR response (derived according to the equation; MAP = CO x TPR) on each clinical investigation day during first 4 hours after consumption of supplements. Mean Arterial Pressure (MAP) and Cardiac Output (CO) will be measured.
Secondary outcome
Acute responses on renal sodium excretion, vasodilating factors and vascular function changes on each clinical investigation day during first four hours after consumption of supplements.
Background summary
AAPRES is a human intervention study with a randomized crossover design that investigates the acute effects of several dietary proteins on blood pressure-related mechanisms.
Study objective
Different dietary proteins have a different effect on blood pressure-related mechanisms.
Study design
6 clinical investigation days with 1 week wash-out on which every hour postprandial measurements will be performed.
Intervention
First 2 weeks weight maintaining standardized diet (15 en% protein, 30 en% fat and 55 en% carbohydrates). Next 6 weeks weekly clinical investigation days on which the acute postprandial effects of different types of protein supplements and different types of carbohydrate supplements will be investigated.
Dep. Human Biology
P.O. Box 616
J. Dopheide
Maastricht 6200 MD
The Netherlands
j.dopheide@maastrichtuniversity.nl
Dep. Human Biology
P.O. Box 616
J. Dopheide
Maastricht 6200 MD
The Netherlands
j.dopheide@maastrichtuniversity.nl
Inclusion criteria
1. Men and women;
2. BMI 25-35 kg/m2;
3. High normal BP or untreated grade 1 hypertension (SBP 130-159 mm Hg and/or DBP 85-99 mm Hg);
4. Age between 20 - 70 years;
5. No smoking;
6. Stable weight in last 3 months (+/- 2 kg).
Exclusion criteria
1. Presence of urinary protein;
2. eGFR < 60 ml/min/1.73 m2;
3. Fasting glucose > 7 mmol/l;
4. Use of prescription medication that could influence BP or vascular function;
5. Gastrointestinal, cardiovascular, pulmonary, liver or renal disease;
6. Food allergies, a special diet or vegetarian;
7. Unwillingness to stop use of vitamin or dietary supplements.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2560 |
| NTR-old | NTR2678 |
| CCMO | NL34527.068.10 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON36655 |