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ID
Source
Brief title
Health condition
Osteoarthritis of the knee is a progressing degenerative joint disorder, characterised by joint pain and limitation of movement, leading to disability. Tissue changes comprise damage of joint cartilage, synovial inflammation and changes in subchondral bone, such as subchondral sclerosis and osteophyte formation (bony outgrowths).
Sponsors and support
Rheumatology & Clin. Immunology and Orthopaedics
Intervention
Outcome measures
Primary outcome
Pain (according to the WOMAC).
Secondary outcome
Functional disability (according to the WOMAC).
Background summary
Introduction:
Joint distraction is a relatively new approach in the treatment of severe osteoarthritis (OA). Clinical efficacy has been proven for hip and ankle OA.
Methods:
Patients with severe posttraumatic OA of the tibio-femoral joint, who were considered for an endoprosthesis were treated with joint distraction. Two external fixation tubes, bridging the knee joint, were placed on pins that were drilled through soft tissue and bone. Joint distraction was performed gradually until 5mm was reached (radiographically controlled). To avoid contractures of the knee joint, each two weeks the distraction tubes were removed from the pins to exercise the joint without loading. After exercising, the distraction of the joint was replaced and controlled radiographically. Absence of mechanical load on the cartilage, preventing further wear and tear, was controlled on standardized radiographs. Pain, functional disability, clinical condition, and flexion of the joint were evaluated using a box-scale, a questionnaire (slightly modified WOMAC) and by physical examination.
Study objective
A two month distraction period results in similar clinical beneficial effects as a three month distraction period.
Study design
N/A
Intervention
Joint distraction applies temporary (2 months) relief of mechanical wear and tear of the articular cartilage surfaces forming a joint. Nutrition of the cartilage is maintained due to intra-articular fluid pressure changes during treatment. Additionally subchondral sclerosis is diminished, diminishing mechanical stresses on the cartilage after treatment.
P.O. Box 85500
A.C.A. Marijnissen
Utrecht 3508 GA
The Netherlands
+31 (0)30 2509758
a.c.a.marijnissen@umcutrecht.nl
P.O. Box 85500
A.C.A. Marijnissen
Utrecht 3508 GA
The Netherlands
+31 (0)30 2509758
a.c.a.marijnissen@umcutrecht.nl
Inclusion criteria
1. Age < 55 years;
2. Osteoarthritis, primary in the tibio-femoral joint, uni or bilateral;
3. Severe osteoarthritis considered for joint replacement surgery/osteotomy.
Exclusion criteria
1. Osteoarthritis in both knees;
2. Primary retro-patellar osteoarthritis;
3. Deviation of the mechanical axis >10 ยบ (independent of cartilage damage);
4. Primary intra-articular inflammation;
5. Psychological problems, not allowing 2 months distraction.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL419 |
NTR-old | NTR459 |
Other | : N/A |
ISRCTN | ISRCTN92846059 |