No registrations found.
ID
Source
Brief title
Health condition
Sarcopenia
Sponsors and support
Intervention
Outcome measures
Primary outcome
fractional synthetic rate
Secondary outcome
• Exogenous phenylalanine rate of appearance and plasma availability of phenylalanine.
• Total rate of phenylalanine appearance and disappearance
• Endogenous phenylalanine rate of appearance
Study objective
Casein ingested within a normal milk matrix results in a more rapid digestion and amino acid absorption, resulting in greater amino acid availability and post-prandial muscle protein accretion as compared to the ingestion of isolated casein (without a milk matrix)
Study design
baseline
2 h
5 h
Intervention
Subjects will be randomly assigned to consume either a drink containing isolated casein or casein in the normal milk matrix. By the use of stable isotope methodology we will assess the digestion and absorption kinetics of the ingested protein source and the fractional synthetic rate (FSR) of muscle proteins in the fasting and fed state in an in vivo human setting.
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Inclusion criteria
- Males
- Aged between 65-85 years
- Healthy, recreationally active
- BMI < 30 kg/m2
Exclusion criteria
- Female
- Smoking
- Allergies to milk proteins (whey or casein)
- Arthritic conditions
- Over the counter antacids
- Diabetes mellitus type 1 and type 2
- A history of neuromuscular problems
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Participation in any regular exercise program
- Chronic use of gastric acid suppressing medication or anti-coagulants
- Unstable weight over the last three months
- Pathologies of the gastrointestinal tract
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4285 |
| NTR-old | NTR4429 |
| Other | METC : 13-3-063.3 |