No registrations found.
ID
Source
Health condition
Gingival inflammation
Sponsors and support
ACTA Dental Research B.V. (ADR)
Gustav Mahlerlaan 3004
1081 LA Amsterdam
The Netherlands
r.bausch@acta.nl
Intervention
Outcome measures
Primary outcome
Microbiological composition
Secondary outcome
Biochemical, immunological and clinical effects
Study objective
We hypothesize this difference is due to differences in the mechanisms by which the individuals can withstand and/or adapt to the stress conditions applied in the clinical model and that these mechanisms are of key importance in our ability to maintain our oral health. We expect that – in analogy of other biological systems – the mouth has intrinsic mechanisms to maintain or restore homeostasis following a perturbance. These processes have up to date gained little attention in research. By examining in detail the dynamic biological responses of the oral ecosystem in individuals during experimental gingivitis induction and relating these responses to individual variation in the inflammatory outcome, it is expected that the biological processes that contribute to our ability to maintain oral health can be identified.
Study design
Day -14, 0, 2, 5, 9, 14, 21
Intervention
Challenge intervention: no oral hygiene for 2 weeks
Intervention: erythritol tablets
Department of Preventive Dentistry
Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam
Gustav Mahlerlaan 3004
Amsterdam 1081 LA
The Netherlands
Department of Preventive Dentistry
Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam
Gustav Mahlerlaan 3004
Amsterdam 1081 LA
The Netherlands
Inclusion criteria
• Adult, ≥ 18 years - 55 year
• Male and female
• Classified as systemically healthy, assessed by medical questionnaire
• Minimum of 20 natural teeth: first and second molars must be present
• Having visited the dentist for a regular check-up within the last year and having finished the necessary treatment.
• Willing and able to give written informed consent
• Willing to consent to use their collected anonymous and coded body materials for further research
Exclusion criteria
• Anyone presenting with a dental pocket probing depth ≥ 5mm with bleeding on probing and attachment loss ≥ 2 mm, Dutch Periodontal Screening Index score 3+/ 4
• >40% BOP
• Overt dental caries
• Smokers, definition non-smoker: <1 cigarette every day for at least one year
• Removable partial dentures
• Removable night guard
• Oral and/or peri-oral piercings
• Apparent oral lesions (aphthous ulcers excluded)
• Presence of orthodontic banding (except for lingual retention wire)
• Abuse of drugs/alcohol
• ACTA dental student or ACTA professional
• Participation in a clinical study within the previous 30 days
General health and use of medication:
• Self-reported pregnancy or breastfeeding
• Use of antibiotics during the last 3 months
• Need of antibiotic prophylaxis prior to dental treatment
• Use of anti-inflammatory drugs on a regular basis
• Evidence of any systemic disease or compromised health condition
• Acute sinusitis
• Severe oral- pharyngeal infections
• Current disorders/disease resulting in (self-induced) vomiting
• Reduced salivary flow due to pathological reasons (e.g. Sjögren syndrome)
• Adverse medical history or long-term medication
• Prescribed medication (except for contraceptives - birthcontrol pills)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4718 |
| NTR-old | NTR4863 |
| Other | : TIFNOH-001-WP2 |