No registrations found.
ID
Source
Brief title
Health condition
Portal vein obstruction
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary and secondary patency after PVO intervention, and patient and graft survival after PVO intervention
Secondary outcome
Prevalence of PVO after liver transplantation, clinical and imaging characteristics of patients before treatment, technical success numbers of all treatment strategies, occurrence of complications after treatment and post-interventional management (especially anticoagulant/antiplatelet prophylaxis).
Background summary
Therapeutic strategies to treat portal vein obstruction (PVO) include percutaneous transluminal angioplasty (PTA) with or without stent, Mesorex Bypass (MRB)/other surgical shunts, endovascular recanalization, endovascular splenic arterial embolisation, splenectomy, and conservative treatment. PTA is the treatment option where the most publications refer to. However, currently only small single centre studies are reported and frequently with different treatment protocols. The primary objective of this study is to assess the efficacy of the individual treatments for PVO after paediatric liver transplantation and determine patient and graft survival. Secondary objectives are to asses prevalence numbers of PVO, technical success, post-treatment complications and medicinal management
Study objective
Not applicable
Study design
Intervention between January 2001 and January 2021 will be retrospectively analyzed
Intervention
No interventions; this is a retrospective, observational registry
Inclusion criteria
1. Treated for PVO (PVAS or PVT) after liver transplantation (all interventions are included and conservative treatment as well)
2. Age at intervention <18 years
3. Intervention in period 01-01-2001 and 01-01-2021
Exclusion criteria
None
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9261 |
| Other | METC UMCG : METc 2021/072 |