In normal weight and overweight/obese young males we expect that - when compared to a single bout of prolonged sitting:(1) sitting on a stability ball will attenuate cardiometabolic health effects;(2) 10-min standing interruptions will not attenuate…
ID
Source
Brief title
Health condition
ENGLISH:
Recent experimental studies on the acute effects of prolonged sitting demonstrated that interruptions during prolonged sitting significantly reduced postprandial glucose, insulin and C-peptide in healthy young adults. Sitting on a stability ball and 10-min standing interruptions may attenuate these negative health effects of prolonged sitting. DUTCH: Recentelijk is aangetoond dat het onderbreken van aaneengesloten zitten een positief effect heeft op postprandiale (d.w.z. na een maaltijd) waarden van glucose, insuline en C-peptide in het bloed. Het is nog onbekend of het actief zitten op een stabiliteitsbal of 10-min durende sta-onderbrekingen de negatieve effecten van aaneengesloten zitten kunnen onderbreken.
Sponsors and support
VU University Medical Center (VUmc)
Intervention
Outcome measures
Primary outcome
The main outcomes of this study are plasma levels of C-peptide, glucose, triglycerides, high-sensitive C-reactive protein (hs-CRP) and saliva levels of cortisol.
Secondary outcome
Secondary outcomes of this study are functioning of the autonomic nervous system, sleep-wake patterns, attention/concentration and mood.
Study objective
In normal weight and overweight/obese young males we expect that - when compared to a single bout of prolonged sitting:
(1) sitting on a stability ball will attenuate cardiometabolic health effects;
(2) 10-min standing interruptions will not attenuate cardiometabolic health effects.
Study design
Plasma levels of C-peptide, glucose, triglycerides, hs-CRP will be collected hourly (i.e. 6 blood samples); saliva will be collected at baseline and at the end of the experimental days.
Intervention
All included young males will undergo three experimental conditions, with a one-week washout period in between conditions:
I. Sitting only (i.e. on a chair with back support; control condition): participants will remain seated for 5 consecutive hours;
II. Sitting (on a chair with back support) and hourly 10-min standing interruptions: participants will stand for 10-min, using a sit-stand desk before returning to the seated position for 50 minutes. This procedure will be repeated 4 times (i.e. first hour is included to obtain a steady-state, with no standing interruption);
III. Sitting on a stability ball (i.e. without back support): participants will sit on a stability ball (i.e. without back support) for 5 consecutive hours.
Teatske Altenburg
van der Boechorststraat 7, room MF-C575
Amsterdam 1081 BT
The Netherlands
020-4441736
t.altenburg@vumc.nl
Teatske Altenburg
van der Boechorststraat 7, room MF-C575
Amsterdam 1081 BT
The Netherlands
020-4441736
t.altenburg@vumc.nl
Inclusion criteria
- Apparently healthy normal weight or overweight/obese males;
- Aged 18-20 years;
- Dutch or English speaking;
- Signed informed consent from the participant (age 18-19) or the participant and both parents (age 17).
Exclusion criteria
- Major acute illness/injury;
- Having diabetes mellitus type II – according to the International Diabetes Federation;
- Physical problems that may limit the ability to perform the experiment (i.e. the standing interruptions or sitting on a stability ball).
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5616 |
| NTR-old | NTR5723 |
| CCMO | NL51407.029.15 |
| OMON | NL-OMON44870 |