No registrations found.
ID
Source
Brief title
Health condition
Subarachnoid hemorrhage. Cerebral vasospasm
Sponsors and support
Intervention
Outcome measures
Primary outcome
Sensitivity and specificity.
Secondary outcome
Prediction of clinically relevant vasospasm.
Background summary
This study is an observation pilot study in which prospectively consecutive patients with a subarachnoid hemorrhage are included. All patients are screened with TCD 2-3 times a week for vasospasm, according to the local management guidelines. Besides TCD, a CT-A scans are made for each patient on day 5 and 10 and in case of clinical deterioration. The results of TCD and CTA are compared and linked to clinical symptoms. In case of clinically symptomatic vasospasm, patients are treated according to a pre-defined protocol which is documenten in the local management guidelines. After finishing the pilot studies, we are planning to set-up a large scale cost-effectiveness study in order to investigate which method is most efficient.
Study objective
Comparison of CT-angiography and Transcranial doppler for the detection of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Study design
TCD 3 times a week
CTA on day 5 and 10 (+/- 1 day)
Intervention
Comparison of CT angiography and Transcranial doppler in the detection of cerebral vasospasm after subarachnoid hemorrhage.
University Medical Center Groningen
Hanzeplein 1
M. Uyttenboogaart
Groningen 9713 GZ
The Netherlands
+31-50-3612400
M.uyttenboogaart@umcg.nl
University Medical Center Groningen
Hanzeplein 1
M. Uyttenboogaart
Groningen 9713 GZ
The Netherlands
+31-50-3612400
M.uyttenboogaart@umcg.nl
Inclusion criteria
Aneurysmal subarachnoid hemorrhage
Age 18 years or older
Inclusion within 4 days after onset
Written informed consent
Exclusion criteria
Very poor prognosis
Renal insufficiency (eGFR < 60 ml/min/1.73m2)
Treatment with metformine
Inability to perform TCD (temporal bone window)
Contraindication for iodinated contrast agent (allergy, m. Kahler, myasthenia gravis, pheochromocytoma, mastocytosis, thyroid cancer, nuclear thyroid scan)
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3985 |
| NTR-old | NTR4157 |
| CCMO | NL41458.042.12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON40069 |