No registrations found.
ID
Source
Health condition
hemodynamics
(cerebral) tissue oxygenation
general anesthesia
Sponsors and support
hanzeplein 1
9713 EZ groningen
050-3616161
Intervention
Outcome measures
Primary outcome
Hemodynamics and tissue oxygenation.
Secondary outcome
Requirement of other vasoactive medication.
Background summary
N/A
Study objective
We hypothesize that administration of intravenous atropine during induction of propofol/remifentanil may have a positive effect on the hemodynamic profile and peripheral and cerebral tissue oxygenation during and after induction of anesthesia.
Study design
Day of surgery.
Intervention
All patients will receive a standard anesthesia based on propofol and remifentanil. During the induction of anesthesia patients will randomly receive either atropine 500ug or saline. If necessary, hemodynamic support will be provided by continuous infusion of norepinephrine as in normal clinical practice to maintain adequate perfusion pressure defined as mean arterial pressure 60 mmHg. Hemodynamic parameters as well as peripheral and cerebral tissue oxygenation and microvascular blood flow will be monitored noninvasively and recorded.
Inclusion criteria
1. Patients requiring general anaesthesia;
2. Patients age 18 years and older;
3. Patient and surgical procedure appropriate for treatment with atropine.
Exclusion criteria
1. Patients refusal;
2. Pregnancy;
3. Patients age < 18 years;
4. Patients in which atropine is contra-indicated.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3470 |
| NTR-old | NTR3622 |
| Other | METC UMCG : 2012/218 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |