No registrations found.
ID
Source
Brief title
Health condition
Psychosis (psychose); Stress (stress); Schizophrenia (schizofrenie).
Sponsors and support
sponsor: NWO (VIDI grant) / NARSAD
Intervention
Outcome measures
Primary outcome
* psychotic reaction
* change in D2 receptor binding
* cortisol reactivity
Background summary
The essence of psychosis is that some individuals abnormally react to stress with psychotic symptoms. This will hereafter be referred to as psychotic reactivity to stress. Psychotic reactivity to stress is thought to be the result of an interaction between genetic and environmental predispositions on the one hand, and the impact of changes in the environment experienced as stressful on the other. However, the origins and mechanisms of psychotic reactivity to stress are still poorly understood, and this project contributes to their elucidation.
Study objective
- The level of psychotic reactivity differs between psychotic trait, state, and illness groups
- Psychotic reactivity is mediated by biological reactivity in terms of dopamine and cortisol reactivity
- The level of psychotic reactivity is influenced by genetic polymorphisms and early trauma
Study design
* momentary assessment (60 measurement points - 10 times a day during 6 days)
* laboratory stress task
Intervention
This is not an intervention study.
The study is about the effect of stress on the brain.
There is a control condition and a stress condition.
Inez Myin-Germeys
Maastricht 6200 MD
The Netherlands
+31 (0)43 3688683
i.germeys@sp.unimaas.nl
Inez Myin-Germeys
Maastricht 6200 MD
The Netherlands
+31 (0)43 3688683
i.germeys@sp.unimaas.nl
Inclusion criteria
All subjects:
1. Aged between 18-50
2. Sufficient command of the Dutch language
3. No intellectual impairment (IQ>80)
For patients:
1. Diagnosis of non-affective psychotic disorder
Exclusion criteria
All subjects:
1. Current use of psychotropic medication
2. Current cannabis dependence
3. Current alcohol dependence
4. Pregnancy
5. Severe endocrine, cardiovascular or brain disease
6. Having metal elements inside the body MRI)
For relatives:
1. A life-time history of psychotic disorder
For controls:
1. A life-time history or family history of psychotic disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1239 |
| NTR-old | NTR1284 |
| Other | CCMO : 22382 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |