No registrations found.
ID
Source
Brief title
Health condition
Barrett's esophagus, esophageal cancer, field cancerization
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary objective of our study is to evaluate the feasibility of using MDSFR combined with OCT for the detection of field cancerization in Barrett esophagus patients.
Secondary outcome
The secondary objective is to investigate the biological background of field cancerization detected by ESS
Background summary
Barrett's esophagus (BE) is a precursor lesion for esophageal adenocarcinoma. Therefore, the current Barrett's surveillance protocol consists of white light endoscopy and random biopsies. Field cancerization is based on the concept that focal cancers arise in tissue areas with random genetic changes. Light scattering spectroscopy might be able to detect this field cancerization and therefore be an innovative approach to improve detection of prevalent neoplasia in BE patients.
In this study, we will evaluate the feasibility of optical detection of field cancerization in BE patients.
Study objective
Screening of esophageal cancer can be improved by the optical detection of field cancerization
Study design
not applicable
Intervention
Optical measurements will be performed on several locations in the esophagus. Biopsies will also be obtained. Brush cytology will be obtained.
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Inclusion criteria
- Age > 18 years.
- Known BE, defined as columnar lined epithelium of the esophagus containing intestinal metaplasia upon biopsy.
- Signed informed consent.
Exclusion criteria
- Contraindications for ER and/or obtain biopsies (e.g. due to anticoagulation, coagulation disorders, esophageal varices).
- Presence of an advanced lesion (e.g. type 0-I or type 0-III) not amendable for endoscopic resection (T1b).
- Presence of erosive esophagitis (Los Angeles classification ¡ÝA).
- Unable to provide signed informed consent.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5628 |
| NTR-old | NTR5735 |
| Other | AMC METC 2015_323 : AMC METC 2015_323 |