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ID
Source
Brief title
Health condition
Systemic antibiotics, microbiota, pediatric patients with cancer, febrile neutropenia.
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Number of specific bacterial groups in feces of pediatric patients
Secondary outcome
- The difference in diversity of the microbiota before and after treatment
- Type of systemic antibiotics
- Laboratory values (Hb, CRP, leukocytes)
- Blood cultures
- Temperature
- Type of nutrition
Background summary
Unbalance between aerobic and anaerobic bacteria in the gastrointestinal tract can result in favoring a potentially pathogenic microorganism, which could cause a bacterial infection. For this reason it is important to identify how systemic broad spectrum antibiotics affect the microbiota during febrile neutropenia in pediatric patients with cancer. To investigate our research question, we will collect feces samples from pediatric patients with cancer during febrile neutropenia in the UMCG at two points during treatment. These samples will be analyzed by using pyrosequencing techniques. We hypothesize that the bacterial content of the gut changes when the patient gets systemic intravenous antibiotics.
Study objective
What is the effect of the systemic antibiotic therapy on the number and diversity of specific bacterial groups in fecal samples of pediatric patients with cancer?
Study design
First and last day of treatment with systemic antibiotics.
Intervention
Collecting fecal samples obtained from feces in commode chair.
Hanzeplein 1
W.J.E. Tissing
Groningen 9713 GZ
The Netherlands
+31 (0)50 3614213
w.j.e.tissing@umcg.nl
Hanzeplein 1
W.J.E. Tissing
Groningen 9713 GZ
The Netherlands
+31 (0)50 3614213
w.j.e.tissing@umcg.nl
Inclusion criteria
- Pediatric patients with cancer hospitalised in University Medical Centre Groningen
- Reason of hospitalization is febrile neutropenia
- Active treatment with systemic antibiotics
Exclusion criteria
- No defecation within the first three days of hospitalization
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5510 |
| NTR-old | NTR5806 |
| Other | Medische Ethische Toetsingscommissie : M15.174103 |