No registrations found.
ID
Source
Brief title
Health condition
CABG, remote preconditioning, cardioprotection
Sponsors and support
Intervention
Outcome measures
Primary outcome
Differences in phosphorylation of PKC-e, p38MAKP, ERK and HSP27, before and after remote preconditioing, as compared to control.
Secondary outcome
N/A
Background summary
The aim of this clinical study is to investigate whether remote ischemic preconditioning induces a phosphorylation of signalling pathway molecules, such as PKC-e, p38MAPK, ERK and HSP27, in human myocardium.
Study objective
Recent clinical data showed that remote ischemic preconditioning attenuates myocardial damage during cardiac surgery. Classic preconditioning is abolished in diabetic patients. We will investigate the molecular effects of remote ischemic preconditioning on the myocardium, in both diabetics and non-diabetics.
Study design
Two myocardial biopsies will be obtained, the first after sternotomy and the second 30 minutes later, but prior to cardiopulmonary bypass.
Intervention
Remote ischemic preconditioning: By inflating a automateic inflator cuff around the upper arm, we will induce forearm ischemia for 5 minutes, followed by 5 minutes of reperfusion. This cylce will be repeated 2 times.
In the control group the cuff will be placed on the upper arm, but no inflating will be done.
University of Amsterdam, Meibergdreef 9
Postbus 22660 H1Z-120
B. Preckel
Amsterdam 1100 DD
The Netherlands
+31 20 5662162,
b.preckel@amc.uva.nl
University of Amsterdam, Meibergdreef 9
Postbus 22660 H1Z-120
B. Preckel
Amsterdam 1100 DD
The Netherlands
+31 20 5662162,
b.preckel@amc.uva.nl
Inclusion criteria
1. CABG surgery with or without valve surgery;
2. Informed consent;
3. Age >18 years.
Exclusion criteria
1. Emergency surgery;
2. Heart failure;
3. Serious pulmonary disease;
4. Kidney failure.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1821 |
| NTR-old | NTR1931 |
| Other | Medical Ethical Committee, AMC, University of Amsterdam : MEC 09/008 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |