No registrations found.
ID
Source
Brief title
Health condition
6 week periods of antihypertensive drug treatment in monotherapy with 3 weeks washout. Drugs: A lisinopril B nebivolol C barnidipine D HCl thiazide E eprosartan.
Sponsors and support
Yamanouchi Benelux
Solvay Benelux
by sponsors
Intervention
Outcome measures
Primary outcome
1. Office blood pressure measured with an automatic device;
2. Side effects measured with a questionnaire.
Secondary outcome
N/A
Background summary
The choice of antihypertensive drugs for individual patients is difficult. We try to make a predictive model depending on class effects of the 5 amin anti-hypertensive drug classes that can later be tested prospectively. The etnic groups in teh trial have been explicitely defined in advance.
Study objective
Interindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.
Study design
N/A
Intervention
6 week periods of antihypertensive drug treatment in monotherapy with 3 weeks washout. Drugs: A lisinopril B nebivolol C barnidipine D HCl thiazide E eprosartan.
P.O. Box 22660
R.P. Koopmans
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
r.p.koopmans@amc.uva.nl
P.O. Box 22660
R.P. Koopmans
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
r.p.koopmans@amc.uva.nl
Inclusion criteria
Subjects with uncomplicated hypertension between the ages of 36 and 60 years.
Exclusion criteria
Serious hypertensive organ damage
co-morbidity.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL344 |
| NTR-old | NTR384 |
| Other | : N/A |
| ISRCTN | ISRCTN08931855 |