No registrations found.
ID
Source
Brief title
Health condition
Microcirculation, Glycocalyx, Cardiac surgery, Heparin, Cardiovascular disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
Perioperative changes in the perfused boundry region (PBR) of the sublingual microvasculature
Secondary outcome
Perioperative changes in plasma markers for shedding of the glycocalyx such as heparan sulfate, hyaluronic acid and syndecan-1
Background summary
The endothelial glycocalyx (EGC) is a gel-like layer that acts as a natural coating for endothelial cells, thereby preventing these cells from having direct contact with circulating blood cells. In order to reduce the inflammatory and procoagulant response during cardiopulmonary bypass in patients undergoing cardiac surgery through contact activation, extracorporeal circuits are coated with a biocompatible surface. In VU University Medical Centre, cardiopulmonary bypass is mostly performed using a heparin-coated extracorporeal circuit in combination with full anticoagulation by heparin infusion. Alternatively, a phosphorylcholine-coated extracorporeal circuit is used, but it is unknown how these different biocompatible-coated extracorporeal circuits will contribute to the preservation of the glycocalyx during cardiac surgery.
Study objective
We assume that the increase of perfused boundry region will be more pronounced with the use of a phosphorylcholine-coated extracorporal circuit then with the use of a heparin-coated extracorporeal circuit.
Study design
Blood will be drawn and several microcirculatory imaging parameters will be measured before surgery (T0), before (T1) and after administration of heparin (T2), after initiation of CPB (T3), after placement of the side clamp (T4), after administration of protamine (T5), after infusion of concentrated red blood cells (T6), 3 hours after the patient has arrived at the ICU (T7), and 24 hours (T8) and 72 hours (T9) following surgery
Intervention
none
VU University Medical Center<br>
De Boelelaan 1117
A.B.A. Vonk
Amsterdam 1081 HV
The Netherlands
VU University Medical Center<br>
De Boelelaan 1117
A.B.A. Vonk
Amsterdam 1081 HV
The Netherlands
Inclusion criteria
adult patients (age 18-85 years) undergoing CABG surgery, informed consent
Exclusion criteria
Re-operation, emergency operation, patients with diabetes mellitus type 1, patients with a history of hematologic or hepatic diseases or renal replacement therapy, patients with a Body Mass Index (BMI) over 35 kg/m2
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL4085 |
NTR-old | NTR4222 |
CCMO | NL45828.029.13 |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |
OMON | NL-OMON38499 |