No registrations found.
ID
Source
Brief title
Health condition
AKI
Biomarkers
Sponsors and support
Intervention
Outcome measures
Primary outcome
Observational study
Secondary outcome
Observational study
Background summary
This prospective observational single centre study was conducted to determine the relationship between NGAL in plasma and urine and the development of AKI in a heterogeneous adult ICU population in which the timing of renal damage is not well defined. The predictive ability of NGAL is determined and it's earlier detection properties compared to functional parameters like serum Creatinine and Cystatin C. Two methods of NGAL detection will be used and their test properties compared.
Study objective
NGAL is an early predictive biomarker for acute kidney injury in a heterogeneous adult ICU population.
Study design
There were eight timepoints for NGAL plasma and urine measurements: T=0, 4, 8, 24, 36, 48, 60 and 72 hours after admission to the ICU.
Intervention
This observational study was conducted in order to determine the ability of NGAL -an early biomarker of tubular damage- to predict the presence and development of Acute Kidney Injury (AKI) in a general adult ICU population. Plasma and urine NGAL were measured using the conventional ELISA for plasma and urine and a rapid bed side immunoassay for plasma. During the study period all consecutively admitted patients were included.
Dept of Intensive Care, H620 <br>
PO Box 2040
Hilde Geus, de
Rotterdam 3000 CA
The Netherlands
h.degeus@erasmusmc.nl
Dept of Intensive Care, H620 <br>
PO Box 2040
Hilde Geus, de
Rotterdam 3000 CA
The Netherlands
h.degeus@erasmusmc.nl
Inclusion criteria
All consequetively admitted patients on a general adult ICU
Exclusion criteria
1. Age under 18
2. Nefrectomy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1345 |
| NTR-old | NTR1405 |
| Other | : MEC2007-135 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |