No registrations found.
ID
Source
Brief title
Health condition
Patients with an increased risk for polyps or cancer
Sponsors and support
Intervention
Outcome measures
Primary outcome
The sensitivity of high resolution white light endoscopy will be compared to that of AFI for detection of polyps and cancer in the colon.
Secondary outcome
N/A
Background summary
An endoscopic video autofluorescence imaging study for detection of Adenomatous Polyps of the colon with patients ad an intermediate and high risk of adenomatous polyps.
Study objective
The aims of the study are:
1. to assess the clinical utility and feasibility of AFI surveillance colonoscopy in patients with intermediate or high risk for adenomatous polyps;
2. to determine the additional value of AFI in the detection of polyps in these patients;
3. to characterize the pit-patterns in the different polyps using NBI.
Study design
N/A
Intervention
High resolution white light endoscopy versus Autofluorescence endoscopy.
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Inclusion criteria
1. Previous adenomatous polyp (polyp-surveillance);
2. Previous adenocarcinoma of the colon for which a partial colectomy was performed;
3. Hereditary non-polyposis colorectal cancer (either genetically proven by a mutation in one of the mismatch repair genes or with a clinical diagnosis according to the Amsterdam II criteria [14]);
4. Positive family history for CRC: a first-degree family-member fullfills one of the revised Bethesda criteria.
Exclusion criteria
1. Familiar adenomatous polyposis;
2. History of inflammatory bowel disease;
3. Severe coagulopathy;
4. Age less than 18 years.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL479 |
| NTR-old | NTR521 |
| Other | : N/A |
| ISRCTN | ISRCTN76121851 |