Pregnant women in the Netherlands do not reach adequate iodine intake
ID
Source
Brief title
Health condition
None, condition: pregnant <12 weeks
Sponsors and support
Intervention
Outcome measures
Primary outcome
Median urinary iodine excretion (µg/d)
Secondary outcome
Thyroglobulin and thyroglobulin antibody concentrations in blood serum Creatinin concentration in urine Urinary volume Smoking status (smoking is interfering with iodine metabolism) Vegan/Vegetarian y/n (soy is competitive for iodine on thyroid) Nutritional intake specifically related to iodine intake (questionnaire) Intake other relevant micronutrients for pregnant
Background summary
During pregnancy, maternal iodine needs are increased and iodine deficiency during pregnancy might lead to pregnancy complications and can affect brain and cognitive development of the foetus. Despite iodine fortification programs, it has been shown that iodine intake in the Netherlands is declining, implicating that also pregnant women are at risk for iodine deficiency. Here we propose to detemine iodine deficiency during pregnancy in the Netherlands, using the golden standard technique of a 24h urine collection combined with serum thyroglobulin concentrations. To this end, in this observational study we will measure the 24h median urinary iodine concentration corrected for urinary volume and creatinin levels in pregnant women, and compare these values with Thyroglobulin (Tg)-concentrations in serum (as measure for iodine intake over a longer period of time). To collect these data, women will visit the research center for a single blood draw (15ml), collect urine for 24h at home and fill out a food-intake questionnaire specific for iodine-rich foods/supplements.
Study objective
Pregnant women in the Netherlands do not reach adequate iodine intake
Study design
3 days during the first trimester in pregnancy. Day 1: visit 1 (30 min), Day 2: urine collection at home, Day 3: visit 2 (10 min)
Intervention
None
Inclusion criteria
Female, 18-45y old, in first trimester of pregnancy, pregnant of singleton
Exclusion criteria
Thyroid-disease or any other metabolic disease, kidney disease, twin-pregnancy
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8297 |
| CCMO | NL70677.068.19 |
| OMON | NL-OMON52954 |