No registrations found.
ID
Source
Brief title
Health condition
Overgewicht, Obesity, Brown adipose tissue, Bruin vet
Sponsors and support
Intervention
Outcome measures
Primary outcome
After TRH administration, compared to saline administration;
- Degree of BAT activity
- Skin temperature
- Blood pressure and heart rate
- Serum thyroid hormones and noradrenaline and normetanephrine
Secondary outcome
The association between BAT acitvity and changes in skin temperature, blood pressure, heart rate, and blood parameters.
Background summary
Brown adipose tissue (BAT) is a classic site of non-shivering thermogenesis in most mammals. BAT thermogenesis is controlled via both neuroendocrine and autonomic pathways, and requires both sympathetic stimulation, and hormonal stimulation via thyroid hormone. We hypothesize that brown adipose tissue activity increases after administration of TRH.
Study objective
Human brown adipose tissue activity will increase after administration of Thyrotropin-Releasing Hormone (TRH).
Study design
The two scans will be separated by at least 7 days and a maximum of 3 weeks.
Intervention
Two 18F-FDG PET-CT scans per patient will be performed of the neck and shoulders to visualize BAT activity. One scan will be performed following intravenous administration of TRH, while the other will be performed following intravenous administration of a saline solution (placebo). During the scans, temperature, heart rate and blood pressure will be monitored continuously. Blood samples for analysis of thyroid hormones will be taken at 7 time points.
Charlotte Heinen
Amsterdam
The Netherlands
+31(0)20-566 6642
c.a.heinen@amc.uva.nl
Charlotte Heinen
Amsterdam
The Netherlands
+31(0)20-566 6642
c.a.heinen@amc.uva.nl
Inclusion criteria
- Male sex
- Age between 30 and 40 years old
- BMI range 19 to 25 kg/m2
Exclusion criteria
- Treated or untreated hypo- or hyperthyroidism
- Renal dysfunction (eGFR >60)
- Use of any medication known to affect thyroid hormone metabolism or the autonomic nervous system
- Any cardiovascular disease
- Recent stay of >2 weeks in the tropics within the last 6 weeks
- The desire to father a child within 1 month
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4993 |
| NTR-old | NTR5512 |
| CCMO | NL45656.018.13 |
| OMON | NL-OMON41582 |