No registrations found.
ID
Source
Brief title
Health condition
PCOS, endometriosis and MRK syndrome
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome is the difference in AGDac in all 4 groups.
Secondary outcome
Other study outcomes are:
- the difference in AGDaf and 2D:4D ratio in the four different patient groups (MRKH vs. PCOS vs. endometriosis vs. controls).
The following parameters will also be monitored: age, ethnicity, BMI, medical history, signs of clinical hyperandrogenism (by questionnaire) and ovarian morphology by ultrasound (to investigate the presence of polycystic ovarian morphology).
Background summary
Mayer Rokitansky Küster Hauser (MRKH) syndrome is a congenital disorder, characterized by aplasia of the uterus and the upper two thirds of the vagina. The aetiology is unknown. We hypothesize that prenatal exposure to AMH is responsible for the development of MRKH in the female. The anogenital distance (AGD) and the ratio between the length of the 2nd and 4th digit (2D:4D ratio) have been described as biomarkers of prenatal androgen exposure. In women with polycystic ovary syndrome (PCOS) longer AGD is reported, suggesting that the origin of PCOS is possibly due to prenatal exposure to androgens. In women with severe endometriosis a decreased AGD has been reported, possibly due to oestrogenic intrauterine influence.
We will perform measurements by digital calliper of the AGD and 2D:4D ratio in women with MRK, PCOS, endometriosis and a control group.
Study objective
We hypothesize that prenatal exposure to AMH is responsible for the development of MRKH in the female. The anogenital distance (AGD) and the ratio between the length of the 2nd and 4th digit (2D:4D ratio) have been described as biomarkers of prenatal androgen exposure. In women with polycystic ovary syndrome (PCOS) longer AGD is reported, suggesting that the origin of PCOS is possibly due to prenatal exposure to androgens. In women with severe endometriosis a decreased AGD has been reported, possibly due to oestrogenic intrauterine influence.
Study design
Only one study visit for completing questionnaire and measurements.
Intervention
- measurement of AGD by digital calliper (AGDac, anterior clitoral surface to the centre of the anus; AGDaf, from the posterior fourchette to the centre of the anus)
- measurement of 2D:4D ratio by digital calliper
- measurement of 2D:4D ratio by computer-assisted analysis
Henrike Peters
Postbus 7057
Amsterdam 1007 MB
The Netherlands
0204440561
h.peters@vumc.nl
Henrike Peters
Postbus 7057
Amsterdam 1007 MB
The Netherlands
0204440561
h.peters@vumc.nl
Inclusion criteria
4 groups:
MRK syndrome:
- Diagnosed with MRK
- age >18 years
PCOS:
- Diagnosed with PCOS
- age >18 years
endometriosis:
- Diagnosed with endometriosis
- age >18 years
Control:
- Age ¡Ý 18 years
- Regular, ovulatory cycle
- ICSI treatment for male infertility
Exclusion criteria
MRK syndrome:
no exlusion criteria
PCOS group:
- vaginal delivery in the medical history
- diagnosed with endometriosis
Endometriosis group:
- vaginal delivery in the medical history
- diagnosed with PCOS
Control group:
- diagnosed with PCOS/endometriosis
- ICSI treatment after a total fertilization failure in IVF cycle
- vaginal delivery in the medical history
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7276 |
| NTR-old | NTR7492 |
| CCMO | NL64437.029.18 |
| OMON | NL-OMON48729 |