No registrations found.
ID
Source
Brief title
Health condition
plasma tyrosine levels, working memory performance
Sponsors and support
Intervention
Outcome measures
Primary outcome
Tyrosine plasma concentrations at T0, T90, T120, T150, T180, T210 and T240 at doses of 100 mg/kg body weight (elderly), 150/kg body weight mg (young and elderly) and 200 mg/kg body weight (elderly)
Secondary outcome
Performance on the n-back task measured by accuracy (total number of hits) and reaction time (ms) on all doses
Study design
T0, T90, T120, T150, T180, T210 and T240
Intervention
100, 150 and 200 mg/kg body weight of tyrosine
P.O. Box 8129
Ondine Rest, van de
Wageningen 6700 EV
The Netherlands
+31 (0)317 485867
Ondine.vandeRest@wur.nl
P.O. Box 8129
Ondine Rest, van de
Wageningen 6700 EV
The Netherlands
+31 (0)317 485867
Ondine.vandeRest@wur.nl
Inclusion criteria
• Aged 18-35 years or aged 60-75 years
• Normal and stable weight (BMI 18.5-25 kg/m2 and weight 50-95 kg)
• Willing to abstain from blood donation during the study
• Willing to comply with study procedures
• Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for at least 15 years.
• Dutch-speaking
• Non-smoking
• Normal or corrected-to-normal vision
Exclusion criteria
• Thyroid problems, such as hyperthyroidism, hypothyroidism, thyroid cancer
• Using medication that can interfere with tyrosine’s action; monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids
• Following a low-protein diet as prescribed by a dietician or physician
• Intestinal problems that affect nutrient absorption (such as coeliac disease)
• Parkinson’s Disease
• Depression
• Use of tyrosine supplements
• Being allergic or having a dislike to the product carrier (banana-flavored yoghurt)
• Bad venous access, as judged by the research nurse
• Personnel of Wageningen UR, Division of Human Nutrition, their partner and their first and second degree relatives
• Current participation in other scientific research
• Mini Mental State Examination (MMSE) score < 24 (to exclude cognitive impaired participants, only for elderly participants)
• Estimated IQ <85 (based on Nederlandse Leestest voor Volwassenen (NLV) -score)
• (History of) clinically significant psychiatric disorder
• (History of) clinically significant neurological disorder, such as brain infarct, chronic migraine, major depression
• Under treatment for cardiac or vascular diseases and use of medication for these conditions
• General medical conditions, such as repetitive strain injury (RSI) or sensori-motor handicaps, as judged by the investigator
• Alcohol consumption of more than 14 (women) or 21 (men) units per week
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4417 |
| NTR-old | NTR4846 |
| CCMO | NL49893.081.14 |
| OMON | NL-OMON41127 |