No registrations found.
ID
Source
Brief title
Health condition
Recurrent miscarriages
cardiovascular disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Blood pressure;
2. Body mass index;
3. Venous blood sampled: Glucose, HbA1c, insulin, total cholesterol, HDL cholesterol, triglycerides and HsCRP;
4. Urine: Microalbumin.
Secondary outcome
Cardiovascular risk profile.
Background summary
Recurrent miscarriages is commonly defined as three or more consecutive miscarriages prior to the 20th week. It is a common problem affecting 1 to 2% of all fertile couples and is a highly heterogeneous condition. An underlying cause may be identified in about 25-50% of cases.
There is increasing evidence that women with hypertension or preeclampsia during pregnancy are at increased of cardiovascular diseases later in life compared to women with normotensive pregnancies. As suggested by previous studies, placenta insufficiency syndrome maybe a first sign of cardiovascular disease, which could also be true for recurrent miscarriages.
Identifying women with risk factors for cardiovascular diseases as early as possible makes it possible for them to benefit from preventive interventions.
Study objective
There is increasing evidence that women with hypertension or preeclampsia during pregnancy are at increased of cardiovascular diseases later in life compared to women with normotensive pregnancies. As suggested by previous studies, placenta insufficiency syndrome maybe a first sign of cardiovascular disease, which could also be true for recurrent miscarriages.
Study design
N/A
Intervention
Assessment of classic cardiovascular risk factors will be performed for women with recurrent miscarriages vs women with an uncomplicated pregnancy in history.
Inclusion criteria
Women who visited the recurrent miscarriages clinic since 2000. The time interval between their first miscarriage and the time of inclusion has to be at least 2 years.
The control group will be derived from the Hyras study. The controls were required to have one or more uncomplicated pregnancy (ies) in their history.
Exclusion criteria
Lactating and pregnant (within the last 3 months) women.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3256 |
| NTR-old | NTR3408 |
| Other | ABR : 40524 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |