No registrations found.
ID
Source
Brief title
Intervention
Outcome measures
Primary outcome
Number of direct laryngoscopies (on a group level) needed to detect (a single) recurrent laryngeal carcinoma.
Secondary outcome
Key:
1. Costs;
2. Operability of a recurrence;
3. Surgical margins of the salvage laryngectomy;
4.Quality of life.
Background summary
N/A
Study objective
N/A
Intervention
Selection for direct laryngoscopy with FDG-PET.
Two strategy arms are compared:
1. Conventional strategy: direct laryngoscopy under general anaesthesia with taking of biopsies
2. PET based strategy: only direct laryngoscopy under general anaesthesia with taking of biopsies if FDG-PET is positive or equivocal.
Boelelaan 1117
R. Bree, de
Amsterdam 1081 HV
The Netherlands
+31 (0)20 4443690
r.bree@vumc.nl
Boelelaan 1117
R. Bree, de
Amsterdam 1081 HV
The Netherlands
+31 (0)20 4443690
r.bree@vumc.nl
Inclusion criteria
1. Patients with clinical suspicion on recurrent laryngeal carcinoma after radiotherapy (without obvious signs of tumour), in whom a direct laryngoscopy under general anaesthesia with taking of biopsies is indicated;
2. T2-T4 laryngeal carcinoma.
Exclusion criteria
1. Age < 18 year;
2. Pregnancy;
3. Radiotherapy within the last 4 months.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL62 |
| NTR-old | NTR93 |
| Other | : ZON-MW 945-04-311 2004/036 (projectnummer VUmc) |
| ISRCTN | ISRCTN89530459 |