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ID
Source
Brief title
Health condition
epilepsy, brain tumor
epilepsie, hersentumor
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Magnetoencephalography
- Epilepsy diary
Secondary outcome
- Neuropsychological assessment
Background summary
Epilepsy is considered a disease in which dynamic processes in the neuronal networks of the brain are dysfunctional. Patients suffering from primary brain tumors often experience epileptic seizures. Up till now, it is unclear which factors are responsible for the large individual variability in the frequency of epileptic seizures in these patients. Magnetoencephalography (MEG) is an imaging technique that is used for detection of seizure activity and epileptic source localization as well as assessment of functional connectivity and neural network features throughout the brain. Recent research advances concerning functional connectivity and network properties of the brain have indicated that these techniques may be used to investigate factors that determine the frequency of epileptic seizures. Functional connectivity and network structure have also proven to correlate with cognitive functioning in brain tumor patients.
The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures, network architecture and cognition in this patient group.
Study objective
- Epilepsy patients with brain tumours show altered functional connectivity and networks in the brain compared to healthy controls
- Connectivity and networks change over time as a function of treatment
Study design
Baseline, before and after each treatment
Intervention
N/A
Afdeling Neurologie, ZH 1F.03/05
Linda Douw
De Boelelaan 1117
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4446027
l.douw@vumc.nl
Afdeling Neurologie, ZH 1F.03/05
Linda Douw
De Boelelaan 1117
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4446027
l.douw@vumc.nl
Inclusion criteria
Inclusion criteria for brain tumor patients:
1. Adult (>18 years)
2. Epilepsy (at least one epileptic seizure)
3. Histopathologically confirmed glioma or meningioma according to the WHO
4. Written informed consent.
Inclusion criteria for healthy controls:
1. Adult (>18 years)
2. Written informed consent.
Exclusion criteria
Exclusion criteria for brain tumor patients:
1. Psychiatric disease or symptoms
2. Insufficient mastery of the Dutch language
3. Inability to communicate adequately.
Exclusion criteria for healthy controls:
1. Use of centrally acting drugs (including analgetics)
2. Psychiatric disease or symptoms
3. Disorders of the central nervous system
4. Insufficient mastery of the Dutch language.
Design
Recruitment
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL1370 |
| NTR-old | NTR1430 |
| Other | METC VU Medisch Centrum : 08/052 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |