No registrations found.
ID
Source
Brief title
Health condition
Cannabis use
Psychotic illness
Sponsors and support
UZ Gasthuisberg en Katholieke Universiteit Leuven, Belgium
Intervention
Outcome measures
Primary outcome
- Striatal and extrastriatal [18F]MK9470 binding.
Secondary outcome
- Differences in striatal and extrastriatal [18F]MK9470 binding as a function of genotypic variation of functional polymorphisms like the COMT Val158Met polymorphism
Background summary
The study aims at contributing to the investigation of the biological mechanism behind the cannabis-psychosis relationship. In order to be able to prevent and to better treat psychotic illness, it is of crucial importance to understand the biological pathway through which THC may be causally related to psychosis, and to identify factors that may moderate this pathway. The distribution of CB1 receptors in dopamine-rich regions, such as the striatum, and dopaminergic projection areas, such as the prefrontal cortex, constitutes a prime candidate. By using PET and [18F]MK9470, striatal and extrastriatal CB1 receptor availability is measured in cannabis users with and without psychotic illness.
Study objective
Cannabis users with and without psychotic illness differ in CB1 receptor availability in striatal and extrastriatal regions as measured with PET and [18F] MK9470
Study design
One timepoint (t0)
Intervention
PET and [18F]MK9470, a CB1 receptor ligand as a measure of CB1 receptor availability in vivo.
Department of Psychiatry and Neuropsychology <br>
PO Box 616 (loc. Vijverdal.)
Cecile Henquet
Maastricht 6226 NB
The Netherlands
+31 (0)43 3688664
cecile.henquet@sp.unimaas.nl
Department of Psychiatry and Neuropsychology <br>
PO Box 616 (loc. Vijverdal.)
Cecile Henquet
Maastricht 6226 NB
The Netherlands
+31 (0)43 3688664
cecile.henquet@sp.unimaas.nl
Inclusion criteria
1. Age 18-50 years
2. Life-time use of cannabis without having experienced negative effects
3. Being capable to consent and having signed informed consent
4. BMI between 18.5 and 27
5. Clinical diagnosis of non-affective psychosis according to DSM-IV (applies only to patients)
Exclusion criteria
1. Head trauma with loss of consciousness of more than 1 hour
2. Respiratory, cardiovasculatory, neurological disease, severe renal or liver dysfunction
3. Alcohol use in excess of 5 units per day
4. Weekly use of illicit drugs other than cannabis
5. Current use of antipsychotic medication or medication known to interfere with the CB1 receptor
6. Pregnancy and breast-feeding
7. Personal or family history of psychosis (applies only to controls)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1379 |
| NTR-old | NTR1439 |
| Other | : 2008-02 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |