No registrations found.
ID
Source
Brief title
Health condition
Complex regional pain syndrome type 1 (CRPS-1)
Sponsors and support
Intervention
Outcome measures
Primary outcome
Pain relief in the first week after blockade as measured 3 times daily in a pain diary with 0=no pain and 10= worst imaginable pain.
Secondary outcome
The following predictors of pain relief after sympathetic blockade will be measured:
1. Pain intensity on a NRS scale of 0 to 10;
2. Subjective and objective skin temperature;
3. Hyper and hypoesthesia;
4. Allodynia;
5. Hyper and hypoalgesia;
6. The presence of dystonia;
7. Tremor and myoclonus.
Background summary
Predictors of pain relief in sympathetic blockade for patients with CRPS-1 will be determined by a standardized evaluation of signs and symptoms in CRPS-1 patiënts with special attention to the existence of a warm or cold fenotype and measurements of skin temperature by means of infrared thermometry.
Study objective
The cold fenotype of CRPS1 is associated with a better respons to percutaneous sympathetic blockade as opposed to the warm type of CRPS1.
Intervention
Upper extremity CRPS-1: percutaneous blockade of Stellate ganglion at C7 with one single injection of bupivacaïne 0,25%
Lower extremity CRPS-1: percutaneous blockade of lumbar sympathetic chain at L3 with a single injection of bupivacaïne 0,25%.
P.O. Box 5800
J. Geurts
Maastricht 6202 AZ
The Netherlands
+31 (0)43 3877673
Jgeurt@sane.azm.nl
P.O. Box 5800
J. Geurts
Maastricht 6202 AZ
The Netherlands
+31 (0)43 3877673
Jgeurt@sane.azm.nl
Inclusion criteria
Adult (18 years or more) male or female patiënts with CRPS1 as diagnosed by IASP criteria, with a duration of 12 months or less with moderate to severe pain (mean NRS of more than 4 in the previous week as measured 3 times daily in a pain diary with 0=no pain and 10= worst imaginable pain) and one extremity involved.
Exclusion criteria
1. Patiënts of less than 18 years of age;
2. The existence of significant impairment of blood coagulation or the use of oral anticoagulant medication;
3. Patients suffering from diabetic polyneuropathia;
4. Patients who are unlikely to comply with study requirements;
5. Pregnant women;
6. CRPS1 with a duration of more than 12 months.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL595 |
| NTR-old | NTR651 |
| Other | : Ministry of economic affairs, number BSIK03016 |
| ISRCTN | ISRCTN71968956 |