No registrations found.
ID
Source
Brief title
Health condition
Primary Immune Deficiency
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. SARS-CoV-2 specific T-cell immunity: CD4+ T cells and CD8+ T cells against SARS-CoV-2 structural proteins (N, M and S)
2. SARS-CoV-2 specific neutralizing antibodies
Secondary outcome
None
Background summary
Goal
Research has shown that persons who are immunocompromised due to different causes, have a higher risk for a severe clinical course of COVID-19. Nevertheless, scarce data in addition to our own experience suggest that persons with a primary immune deficiency, mainly common variable immune deficiency (CVID) do not have a higher risk for a severe clinical course. In this study, we will determine the SARS-CoV-2 specific T-cell and neutralizing antibody responses in persons with a primary immune deficiency who have had COVID-19 in the past months.
Population
Persons with a primary immune deficiency who are being monitored at the Leiden University Medical Center (LUMC) of 18 years or older, who have had COVID-19
Endpoints
SARS-CoV-2 specific T-cell immunity and SARS-CoV-2 neutralizing antibodies of persons with PID who have had COVID-19 compared to persons without PID who have had COVID-19
Study objective
Persons with a primary immune deficiency do have SARS-CoV-2 specific T-cells, neutralizing antibodies or both
Study design
One time point during CVOID-19 or after having recovered from COVID-19
Intervention
None
Inclusion criteria
- age 18 or older
- diagnosed with primary immune deficiency and a patient at the Leiden University Medical Center
- proof of having had COVID-19 by PCR, either by GGD (municipal Health Center) of LUMC
Exclusion criteria
- vaccinated against SARS-CoV-2
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9277 |
| Other | METC Leiden Den Haag Delft : N L76388.058.20 |