No registrations found.
ID
Source
Brief title
Health condition
Larynx and hypopharynx carcinoma
Sponsors and support
Intervention
Outcome measures
Primary outcome
The effect of imaging variables (e.g. apparent diffusion coefficient, tumor volume, and dynamic contrast enhanced MRI variables) on treatment outcome.
Secondary outcome
The effect of clinical variables (e.g. smoking status and tumor stage) on treatment outcome
Background summary
More and more laryngeal and hypopharyngeal patients receive larynx-preservation treatment instead of total laryngectomy (TLE). However, for some patients, treatments like primary radiotherapy might not be suitable and they risk undertreatment. This study aims to find imaging features on pretreatment imaging that predict outcome of radiotherapy in order to optimise patient selection for this treatment. This can help treatment decision making and increase survival rates.
Study objective
We expect to find that tumor volume, as well as dynamic contrast enhanced MRI variables will be prognostic variables of treatment outcome
Study design
This is a retrospective study, we will gather clinical and treatment related data, as well as imaging from the time of diagnosis until last follow-up.
Intervention
Radiotherapy with or without chemotherapy
Inclusion criteria
Patients with larynx or hypopharynx carinoma primarily treated with radiotherapy with curative intent with or without additional chemotherapy. Treated in UMC Utrecht in the period of January 2008 and March 2020. Follow-up of at least 2 years or until recurrence. Available MRI imaging of the tumor site is made within 4 weeks before the start of the radiotherapy treatment.
Exclusion criteria
History of carcinoma at the time of diagnosis. Distant metastasis or second primary tumours at time of diagnosis.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9212 |
| Other | METC Utrecht : METC 20-340 |