No registrations found.
ID
Source
Brief title
Health condition
Cardiac valve surgery +/- CABG.
Sponsors and support
Intervention
Outcome measures
Primary outcome
90-days mortality and causes of deaths.
Secondary outcome
1. In-hospital mortality, 30- and 60-days mortality, onset and type of postoperative infections, onset and type of multiple-organ-dysfunction-syndrome (MODS), ICU-stay, hospital-stay and long-term survival. Pro-and anti-inflammatory cytokine profile, complement system activation and inflammatory mediators.
2. Cost-effective-analysis for the primary outcome.
Background summary
The primary outcome and some secondary outcomes are published. The analysis of blood samples are still continuing and the long-term analysis is still ungoing.
Study objective
To investigate the role and mechanisms of leukocytes in allogeneic erythrocyte concentrates on postoperative complications, as MODS, infections and death.
Study design
N/A
Intervention
Randomization to receive buffy-coat-depleted (PC) or leukocyte-depleted transfusions when necessary. Pre-operative, at arrival at ICU and day 1 postoperatively at ICU blood samples were obtained.
Plesmanlaan 1a
Y.M. Bilgin
Plesmanlaan 1a
Leiden 2333 BZ
The Netherlands
+31 (0)71 5685053
bilginyavuz@hotmail.com
Plesmanlaan 1a
Y.M. Bilgin
Plesmanlaan 1a
Leiden 2333 BZ
The Netherlands
+31 (0)71 5685053
bilginyavuz@hotmail.com
Inclusion criteria
Patients undergoing valve surgery (+/- CABG).
Exclusion criteria
Patients under 18 years of age, patients with medical indications for leucocyte-depleted erythrocytes and who received blood transfusions within previous 3 months.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL298 |
| NTR-old | NTR336 |
| Other | : N/A |
| ISRCTN | ISRCTN68522192 |
Summary results
Transfus Med. 2005 Jun;15(3):209-17.