No registrations found.
ID
Source
Brief title
Health condition
Subfertility
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ongoing pregnancy rate per patient couple (positive fetal cardiac activity 10 weeks after IUI).
Secondary outcome
Clinical pregnancy rate per IUI cycle (HCG> 50 IU /l at 16 days after IUI). Ongoing pregnancy rate per IUI cycle (positive fetal cardiac activity 10 weeks after IUI). Percentage multiple pregnancies Percentage biochemical pregnancies and abortions Percentage/number of live births.
Background summary
A single centre randomized controlled trial to evaluate if the pregnancy rate, number of ongoing pregnancies and the number of live births after IUI increases as the time between the production of semen and the IUI is shortened in couples with unexplained, cervical factor or male subfertility at the VU University Medical Center, The Netherlands.
Study objective
To evaluate if the pregnancy rate, number of ongoing pregnancies and the number of live births after IUI increases as the time between the production of semen and the IUI is shortened.
Study design
N/A
Intervention
Patients are inseminated approximately 3-4 hours after the production of semen (Group I, current practice VUmc) or patients are inseminated as soon as possible after the production of semen (Group II, intervention group).
PO box 7057
C.G. Vergouw
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4443229
carlijn.vergouw@vumc.nl
PO box 7057
C.G. Vergouw
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4443229
carlijn.vergouw@vumc.nl
Inclusion criteria
Patients who start their first IUI treatment. All subsequent cycles fall within this study. Only patients who undergo six IUI cycles, three times in a natural cycle and three times in a stimulated cycle, fall within this study. Patients who start a new IUI treatment after an ongoing pregnancy. Both IUI performed in a natural cycle and stimulated cycles fall within this study. Patients with well-adjusted, non-endocrine hormonal pathology fall within this study.
Exclusion criteria
Patients who have IUI with donorsemen. Patients in which the semen was obtained in a different way than masturbation (bladder irrigation, electrical stimulation). Patients who have less than 0.5 million progressive motile sperm left over after work-up of semen. Patients with polycystic ovarian syndrome (PCOS). Patients with imminent ovarian failure (basal FSH> 10 IU / l).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2996 |
| NTR-old | NTR3144 |
| Other | METc VUmc : 2011/219 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |