No registrations found.
ID
Source
Brief title
Health condition
Subfertility
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcomes were live birth and clinical pregnancy.
Secondary outcome
(1) biochemical pregnancy, (2) mean number of amniotic sacs, (3) mean implantation ratio (defined as the number of amniotic sacs present divided by the number of embryo’s transferred), (4) miscarriage rate, (5) ectopic pregnancy rate (6) ongoing pregnancy rate and (7) difficult embryo transfer
Background summary
*The correct date of registration is 15-01-2019.*
Rates of elective CSs are rising worldwide. Late sequaelae of CSs related to a niche (CSdefect) include gynaecological symptoms and obstetric complications. A systematic review of Gurol-Urganci (2013) reported a lower pregnancy rate after a previous CS (RR 0.91 CI 0.87-0.95) compared to a previous VD. However the underlying cause is unclear, included studies do not differentiate between indication for fertilisation, embryo transportation, or embryo implantation. Using an IVF population offers the possibility to study the effect of a previous CS on the implantation of embryo’s in relation to a previous VD.
Study objective
A previous caesarean section does affect the reproductive outcomes including live births in women after In Vitro Fertilization or Intracytoplasmic Sperma Injection.
Study design
n.a.
Intervention
None
Inclusion criteria
In this retrospective cohort study all secondary infertile women with only one previous delivery who underwent an IVF or ICSI treatment at the IVF centre, Amsterdam UMC, location VU university, Netherlands between 2006 and 2016, were included. Only the first fresh embryo transfer was taken into account in the analyses.
Exclusion criteria
Patients without an intention for embryo transfer were excluded.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7631 |
| Other | METC Vumc : METC 2019.057 |