This research aims to determine factors involved in subfertility and serious pregnancy complications that arise early in pregnancy. Due to increased insight into the pathogenesis of these conditions, primary prevention should ultimately be possible.
ID
Source
Brief title
Condition
- Foetal complications
Synonym
Research involving
Sponsors and support
Intervention
- Other intervention
Outcome measures
Primary outcome
Fertility parameters, embryonic, fetal and placental growth parameters
Secondary outcome
Maternal and paternal health and diseases, epigenetic profiles in parents and child
Background summary
This study will lead to a better understanding of the pathogenesis of these diseases, an improved (already preconception) risk selection and possibly ultimately result in primary and secondary preventive strategies with regard to subfertility, pregnancy complications, and cardiovascular diseases later in life.
Study objective
This research aims to determine factors involved in subfertility and serious pregnancy complications that arise early in pregnancy. Due to increased insight into the pathogenesis of these conditions, primary prevention should ultimately be possible.
Study design
It is an observational cohort study that uses the data collected in the context of regular care as much as possible. Women can be included before pregnancy (preconception) and until 10 weeks of pregnancy.
Intervention
Not applicable
Study burden and risks
Venipuncture are part of the study and have minimal risks. There are ultrasound examinations and questionnaires which take time.
R.P.M. Steegers-Theunissen
The Netherlands
r.steegers@erasmusmc.nl
R.P.M. Steegers-Theunissen
The Netherlands
r.steegers@erasmusmc.nl
Age
Inclusion criteria
- You have a child wish
- You are less than 10 weeks pregnant
- You are 18 years or older
- You are pregnant with a singleton
- You are being monitored by the Department of Obstetrics & Gynecology of Erasmus MC or you
have been monitored by the Department Reproductive Medicine of Erasmus MC
Exclusion criteria
- Oocyte donation
- You are not the biological father of the (unborn) child
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4115 |
| NTR-old | NTR4356 |
| Other | METC-nummer: 2004-227 : TRC-nummer: R32 |
Summary results
• Melek Rousian, Sam Schoenmakers, Alex J Eggink, Dionne V Gootjes, Anton HJ Koning, Maria PH Koster, Annemarie GMGJ Mulders, Esther B Baart, Irwin KM Reiss, Joop SE Laven, Eric AP Steegers, and Régine PM Steegers-Theunissen Cohort Profile Update: the Rotterdam Periconceptional Cohort and embryonic and fetal measurements using 3 D ultrasound and virtual reality techniques. Int J. Epidemiol. 2021 Oct; 50(5): 1426-1427l.