Greater age will be associated with a lower mitoVO2 and mitoPO2. Comorbidities likewise will be associated with a lower mitoVO2 and mitoPO2
ID
Source
Brief title
Health condition
Diabetes Mellitus type II, Obesity, and Neurodegenerative diseases
Sponsors and support
Intervention
Outcome measures
Primary outcome
- To investigate the association between age and mitoPO2 values
Secondary outcome
- To investigate the association between age and mitoVO2 values. - To examine the association between diabetes, obesity and neurodegenerative disease and mitoPO2/mitoVO2 values. - To compare mitoPO2 and mitoVO2 measurements performed on the sternum as opposed to the mitoPO2 and mitoVO2 measurements performed on the upper arm
Background summary
A new technique to measure mitochondrial oxygen tension was recently developed and calibrated by our lab. With this technique, mitochondrial oxygen tension ‘mitoPO2’ and mitochondrial oxygen consumption ‘mitoVO2’ can be measured in human skin. This led to the introduction of the COMET, an acronym of Cellular Oxygen METabolism (COMET, Photonics Healthcare B.V. Utrecht) which enables bed-side monitoring of mitoPO2 and mitoVO2 in real time. Previous studies have illustrated the potential of these measurements in various clinical conditions, unfortunately the influence of aging and chronic disease has not been examined. Before the COMET monitor can be used in clinical settings, it has to be known if these factors have any influence on the measurements. This study will therefore, examine the association between age and mitoPO2 and mitoVO2 values. Secondly, it will investigate whether there is any association between comorbidity and mitoPO2.mitoVO2. Lastly, the study will evaluate ifmitoPO2 and mitoVO2 values differ between measurement location namely, the upper arm or sternum. This is because measurement locations vary in different clinical settings.
Study objective
Greater age will be associated with a lower mitoVO2 and mitoPO2. Comorbidities likewise will be associated with a lower mitoVO2 and mitoPO2
Study design
Measurement day
Inclusion criteria
Healthy Volunteers - Aged ≥ 18 and ≤ 90 years old - Acceptable proficiency of the Dutch language - Healthy volunteers without physical or mental illness Comorbidity group - Aged ≥ 18 and ≤ 90 years old - Acceptable proficiency of the Dutch language - One of the underlying illnesses: neurodegenerative disease, diabetes mellitus type II or obesity (BMI>30), no other relevant comorbidity
Exclusion criteria
- Porphyria - Known intolerance to components of the ALA plaster - Presence of mitochondrial disease - Pregnancy/lactation - Patients with skin lesions on the measurement location which impede measurements - Incapability to provide inform consent, due to a mental condition interfering with the ability to understand the provided information
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9670 |
| CCMO | NL76685.078.21 |
| OMON | NL-OMON51166 |