No registrations found.
ID
Source
Brief title
Health condition
1. Hypertension (hypertensie);
2. high blood pressure (hoge bloeddruk);
3. mild renal insufficiency (milde nierfunctiestoornissen).
Sponsors and support
Intervention
Outcome measures
Primary outcome
Forearm blood flow (FBF).
Secondary outcome
ADMA (asymmetric dimethylarginine) concentration in the blood.
Background summary
In this study the relationship between the systemic NO-mediated endothelium-dependant vasodilatation, measured as forearm blood flow and venous ADMA-level is studied, in hypertensive as well as healthy subjects. In the hypertensive subjects it also will be examined to what extend the forearm blood flow (FBF) can be influenced by treatment with an angiotensin-II- receptorblocker (eprosartan) and/or a statin (rosuvastatin).
Study objective
The ADMA-level in hypertensive subjects will be reversely related to the basal blood flow and the endothelial NO-availability in the forearm. Pre-treatment with an angiotensin-II- receptorblocker and/or a statin will decrease the ADMA-levels via increased clearance of ADMA and, consequently, will ‘normalise’ the forearm blood flow and NO-availability.
Study design
Baseline forearm blood flow measurement (without medication) at t=0. Second forearm blood flow measurement 3 weeks later.
Intervention
The patients will be treated with eprosartan 600 mg and/or rosuvastatin 20 mg during a three-weeks interval.
Department of Internal Medicine
A.A. Kroon
P. Debyelaan 25
Maastricht 6229 HX
The Netherlands
+31 (0)43 3875100
akr@sint.azm.nl
Department of Internal Medicine
A.A. Kroon
P. Debyelaan 25
Maastricht 6229 HX
The Netherlands
+31 (0)43 3875100
akr@sint.azm.nl
Inclusion criteria
1. Hypertension (without medication blood pressure >140/90 mmHg and <180/110 mmHg);
2. creatinine clearance 60-90 ml/min;
3. microalbuminuria (30-300 mg albumin/24 hours);
4. age 18-75 years;
5. BMI between 18 and 30 kg/m2.
Exclusion criteria
1. Diabetes mellitus;
2. contra-indication for use of an angiontensin-II-receptorblocker or statin.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1071 |
| NTR-old | NTR1104 |
| Other | : 2605 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |