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ID
Source
Brief title
Health condition
fundamental study in underlying mechanisms of social behaviour
Sponsors and support
Heidelberglaan 2
3584 CS Utrecht
j.vanhonk@uu.nl
Intervention
Outcome measures
Primary outcome
Differences in blood oxygen level dependent (BOLD) response between OT administration and placebo will be measured.
Secondary outcome
2 questionaires will be obtained
Background summary
To gain insight in the neurobiological mechanisms behind oxytocin
effects on human social-emotional behaviour, the following study will
investigate the neural mechanisms of human sociality combined with
oxytocin administration. A within subjects, double-blind counterbalanced
placebo controlled design will be used. One group of subjects will
participate in both experimental and placebo condition. Procedures on
both days are identical and consist of an explanation of the tasks to be
performed, the administration (placebo or OT nasal spray) followed by an
functional Megnatic Resonance Imaging scan during which 3 tasks
investigating the neural mechanisms of social are to be performed and
an anatomical scan is made. Contrasting task related Blood oxygen level
dependent activation within the group between placebo and OT can show
specific activation related to OT administration.
Study objective
Oxytocin has effect on neural areas involved in human social emotional functioning
Study design
2 timepoints, 1 for placebo, 1 for experimental condition
Intervention
Participants will self-administer 24 IU OT nasal spray. This nasal spray
contains a synthetic version of OT which is identical to the human
pituitary version of OT under the registered name Syntocinon. The
placebo condition will consist of the same nasal administration without
the active ingredient OT. Nasal spray administration is an effective way
of delivering OT in the central nervous system via the nasal mucous
membrane, without substantial side effects (Born et al., 2002; Kosfeld
et al., 2005).
Inclusion criteria
1. Good health
2. Age between 18 and 30
3. Normal or corrected to normal vision
4. Right-handedness
Exclusion criteria
1. Oversensitivity for OT or carrier
2. Use of psychotropic medication, or of recreational drugs over a period of two weeks prior to each experiment, and no use of alcohol within the last 24 hours before each measurement.
3. Habitual smoking
4. History of psychiatric treatment or current psychiatric treatment
5. History of neurological treatment or current neurological treatment
6. History of endocrinological treatment or current endocrinological treatment
7. Irremovable ferrous objects in or around the body (e.g. pacemaker, stents, splinters)
8. History of closed head injury
9. History of epilepsy
10. Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL1394 |
| NTR-old | NTR1454 |
| Other | : |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |