No registrations found.
ID
Source
Brief title
Health condition
Covid-19 infection
Sponsors and support
Intervention
Outcome measures
Primary outcome
- BMI
- Hip- waist ratio
- Covid-19 laboratory test (Ferritin, triglycerides, HDL-cholesterol, CRP, procalcitonin, ALAT, ASAT, GGT, AF, glucose, LDH, sodium, potassium
- CT-scan; CO-RADS and severity score
- Medication use (statins, inhalation corticosteroids, antihypertension medication etc.)
- Severity of covid-19 infection defined by hospitalization, oxygen suppletion and intubation and ventilation at the intensive care.
- Outcome after 30 days (complete recovery, rest abnormality, deceased)
Secondary outcome
- Diameter of fat on sternum (measuring on the CT at xyphoid)
Background summary
Covid-19 is a novel infectious disease of pandemic proportions, which started in Wuhan in 2019. Previous studies, mostly originating from China, showed that the outcome and mortality was more severe in covid-19 patients with co-morbidities, like cardiovascular disease, diabetes mellitus and hypertension.
In clinical observational studies, 80% of the PCR-proven covid-19 patients in the Intensive Care Unit are overweight or morbidly obese, however the ratio of waist-hip circumference is not investigated yet. This could possibly be an important predictor for the severity of the covid-19 clinical course. Thereby, it is not known if the obese patients with covid-19 comply with the criteria of the metabolic syndrome.
Identifying risk factors for a more severe clinical course is necessary for optimizing treatment. The prevalence of metabolic syndrome is high worldwide, but it’s relationship with the severity of a covid-19 infection is still unknown.
Study objective
The aim of the study is to explore the relation between metabolic syndrome and the severity of covid-19 in the first 30 days of diagnosis.
Study design
Day 1 (ER visit); day 30
Intervention
Any patient with a suspicion of covid-19 infection at the ER, the criteria of the metabolic syndrome were screened; glucose, hypertension (>130/85 mmHg and/ or medication), low HDL-cholesterol (men ≤1,04 mmmol/l; women ≤ 1,29 mmol/l), high triglycerides (men and women ≥ 1,7 mmol/l or statin use), abdominal obesity (hip and waist measurement in cm).
Inclusion criteria
Age > 18 years old and no treatment restrictions
Exclusion criteria
Patient not able to stand straight, this is necessary to measure the hip-waist ratio.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8580 |
| Other | Franciscus Gasthuis en Vlietland Raad van Bestuur : 2020-041 |