No registrations found.
ID
Source
Brief title
Health condition
Obesity
Sponsors and support
Intervention
Outcome measures
Primary outcome
- RNA expression levels and subsequent pathway analysis in subcutaneous adipose tissue and skeletal muscle
- Change in levels of cytokines, adipokines and myokines
Secondary outcome
- Insulin sensitivity
- Cardiorespiratory fitness
- Body composition
Study design
Baseline, at 2 and 4 weeks during intervention and at 8-weeks (after cessation of the trianing period)
Intervention
- training intervention (8 week aerobic exercise training)
- subcutaneous adipose tissue biopsy
- skeletal muscle biopsy
- venous blood sampling
- hyperglycemic euglycemic clamp
- DXA scan
- Maximal cycling test
Rebecca Verheggen
Philips van der Leijdenlaan 15
Nijmegen
The Netherlands
0243614906
rebecca.verheggen@radboudumc.nl
Rebecca Verheggen
Philips van der Leijdenlaan 15
Nijmegen
The Netherlands
0243614906
rebecca.verheggen@radboudumc.nl
Inclusion criteria
- Body mass index of > 28 kg/m2
- ¡Ý 18 years of age
- Mentally able/allowed to give informed consent
Exclusion criteria
General exclusion criteria
- Use of medication interfering with fat metabolism (thiazolidinediones)
- Type 1 or 2 diabetes mellitus
- Nicotine abusus
- Use of anticoagulant therapy
- Lidocain allergy
- Acute myocardial infarction (3-5 days)
- Unstable angina
- Uncontrolled arrhythmias causing symptoms or hemodynamic instability
- Syncope
- Active endocarditis
- Acute myocarditis or pericarditis
- Symptomatic severe aortic stenosis
- Uncontrolled heart failure
- Acute pulmonary embolus or pulmonary infarction
- Thrombosis of lower extremities
- Suspected dissecting aneurysm
- Uncontrolled asthma
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5630 |
| NTR-old | NTR5737 |
| CCMO | NL50995.091.14 |
| OMON | NL-OMON42108 |