No registrations found.
ID
Source
Health condition
Cystic Fibrosis
Primary Ciliary Dyskinesia
Sponsors and support
Academic Medical Centre, University of Amsterdam
Intervention
Outcome measures
Primary outcome
1. Relative changes in electronic nose sensors;
2. Retention time;
3. Abundance and mass to charge ratio from GC-MS analysis.
Secondary outcome
(Change in) bacterial and viral diversity.
Background summary
N/A
Study objective
N/A
Study design
3 monthly collection of study samples and during an exacerbation.
Intervention
Longitudinal observational study during one year with collection of 5 exhaled breath and microbiology samples.
T. Paff
Department of pulmonology
VU University Medical Center, Amsterdam
Room PK 4X 023
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4445491
t.paff@vumc.nl
T. Paff
Department of pulmonology
VU University Medical Center, Amsterdam
Room PK 4X 023
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4445491
t.paff@vumc.nl
Inclusion criteria
1. CF diagnosis is based on: clinical symptoms in combination with an abnormal sweat test (chloride > 60 mmol/l) and/or identification of mutations in both alleles of the CFTR gene;
2. PCD diagnosis is based on: A combination of clinical symptoms, abnormal movement of cilia on microscopic evaluation of respiratory epithelial biopsies and epithelial cell cultures, or identification of an ultra structural defect in the cilia by electron microscopy;
3. ≥ 6 years of age;
4. Stable respiratory disease for at least 6 weeks ( as determined by the treating physician);
5. Ability to perform lung function measurement.
Exclusion criteria
1. Mental retardation;
2. Diabetes Mellitus (CF complication);
3. Technical unsatisfactory performance of measurements;
4. On the waiting list for lung transplantation;
5. Participation in the PREVEC or VERTEX study (AMC).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3464 |
| NTR-old | NTR3616 |
| Other | : |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |