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ID
Source
Brief title
Health condition
Glucosemetabolisme, metabole gezondheid
Sponsors and support
Intervention
Outcome measures
Primary outcome
blood glucose and insulin levels
Secondary outcome
continuous glucose during 48 h, appetite ratings, side effects
Background summary
L-arabinose is a pentose which is naturally present in plants. L-arabinose is a sucrase inhibitor and thereby lowers glycaemic and insulinemic responses when consumed together with sucrose as a drink in young healthy subjects. Still, we don’t know if this effect is also observed in subjects that are less able to regulate their glucose levels. Further, long term effects such as 24h or 48h glucose responses are scarce.The main objective is to determine the effect of drinking a solution of sucrose with arabinose on glycemic responses in prediabetic subjects. Secondary objectives are continuous glucose responses, appetite ratings, tolerance of the treatments, L-arabinose in the blood, and excretion of L-arabinose in urine. The study is a randomized double-blind cross-over study with a washout period of 5 days. Eighteen subjects between 55-80y old with increased risk of developing type II diabetes will be included. The drinks will be consumed in fasting state as a breakfast. Further, lemonades with or without arabinose will be provided to drink before every meal during 48h, when meanwhile continuous blood glucose is measured.
Study objective
Addition of arabinose lowers glycemic repsonses in subjects at risk of developing type 2 diabetes
Study design
Every subject will visit University 5 times, an information meeting, a screening including a fasting glucose, Hb and HbA1c, 2 test days and removal of the glucose sensor.
Plasma collection: 0, 15, 30, 45, 60, 90, 120, 180 minutes.
Intervention
Sugar drink with and without arabinose. And arabinose supplementation during 2 days
Korrie Pol
Postbus 8129
Wageningen 6700 EV
The Netherlands
korrie.pol@wur.nl
Korrie Pol
Postbus 8129
Wageningen 6700 EV
The Netherlands
korrie.pol@wur.nl
Inclusion criteria
- Age range of ≥ 55 and < 80 years old,
- BMI ≥ 25 <40 kg/m2,
- Impaired fasting glucose (IFG; fasting glucose ≥ 5.6 and < 7.0 mmol/L) or
- HbA1C: ≥ 39 < 49 mmol/mol
Exclusion criteria
- Diagnosed with diabetes,
- Having other diseases, including amongst others liver, pancreas and endocrine diseases, which could affect the study results.
- Having gastro-intestinal problems,
- Use of medications or supplements that could influence the study results (chronic medications or supplements should be used as normal),
- Allergy, intolerance or oversensitivity for food products,
- Sensitive to medical skin adhesives,
- Following a medically prescribed, low energy or low carbohydrate diet,
- Unwilling to consume the provided diets,
- More than 5kg weight change in the last 3 months,
- Current antibiotics usage or in the two months prior to the first test day,
- Excessive alcohol consumption (>21 glasses/week for men and >14 glasses/week for women on average),
- Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse,
- Not normal haemoglobin (Hb) concentration <8.5 mmol/L for men and <7.5 mmol/L for women,
- Recent blood donation (<1 month prior to the first study day),
- Planning to donate blood as a blood donor during the study,
- Mentally incompetent or not being able to perform the measurements according to the protocol,
- Not having a general practitioner,
- Being an employee of Wageningen University, division of Human Nutrition and Health,
- Current participation in other research (except EetMeetWeet).
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6761 |
| NTR-old | NTR7630 |
| CCMO | NL66558.081.18 |
| OMON | NL-OMON45845 |