No registrations found.
ID
Source
Brief title
Health condition
EN: red blood cell transfusion, clearance, microcirculation, sepsis, intensive care medicine
NL: rode bloedcel transfusie, klaring, microcirculatie, sepsis, intensive care
Sponsors and support
Intervention
Outcome measures
Primary outcome
Phosphatidylserine exposure on donor RBCs
Secondary outcome
- Clearance of erythrocytes
- Expression of clearance markers other than PS
- Markers of immune cell and endothelial cell activation and adhesion
- Complete blood count
- Levels of fibrinogen, APTT, PTT and D-dimers in blood (to calculate DIC score)
- Markers of inflammatory host respons
- Sublingual microcirculatory density and perfusion velocity, as visualized with SDF
- Tissue oxygenation, as measured with NIRS
- Time on mechanical ventilation
- Duration of ICU stay
- Duration of hospital stay
- 28 day mortality
- DNA staining on residual red blood cell material,
- Red blood cell deformability, activation status and cell-binding ability
- Oxygen tension in the mitochondria (MitoPO2)
Background summary
Inclusion are going to take place in the Academic medical centre, Amsterdam, the Netherlands
Study design
Before transfusion and 1, 24 hours and 48 hours after transfusion
Intervention
Patients will receive biotinylated blood to be able to distinguish the donors blood from the patients own blood
N.P. Juffermans
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662509
n.p.juffermans@amc.uva.nl
N.P. Juffermans
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662509
n.p.juffermans@amc.uva.nl
Inclusion criteria
- Patients must receive an erythrocyte transfusion on the ICU, to correct for anemia
- Patients may not have received a transfusion with red blood cells, plasma or thrombocytes in the previous 24 hours
- Patients may not receive more than 1 unit of RBCs
- Patients may not be suspected of having an active bleeding
Exclusion criteria
- Patients who have not given informed consent
- Patients who pose difficulties in securing blood products (e.g. rare blood groups)
- Patients who receive more than 1 unit of RBCs in 1 transfusion episode
- No arterial catheter in situ
- Patients who received biotinylated blood before (earlier enrollment in TETRIS2)
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6419 |
| NTR-old | NTR6596 |
| CCMO | NL61833.018.17 |
| OMON | NL-OMON48722 |