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ID
Source
Brief title
Health condition
Anxiety and stress-related psychiatric disorders such as PTSD
Sponsors and support
Intervention
Outcome measures
Primary outcome
Reactions to threat of shock
Secondary outcome
Working memory (Emotional N-Back task); Inhibitory control (emotional Go/NoGo task); Neural activity in rest and during cognitive tasks in a threat context (EEG).
Background summary
For adequate functioning in situations of threat and to prevent the risk on stress-related mental-health problems, sufficient self-regulation capacity is needed. Self-regulation skills have a strong link with the dorsolateral prefrontal cortex (DLPFC). Transcranial direct current stimulation (tDCS) to the DLPFC may increase self-regulation capacity, probably through enhancing DLPFC-dependent executive functions such as working memory. The goal of our study is to investigate the benefits of a tDCS intervention for self-regulation capacity under threat.
Subjects undergo a 3-session tDCS intervention targeting the DLPFC combined with working memory training. We will investigate if this intervention improves control over reactions to threat (mild electrical shocks). Moreover, we will verify if this intervention improves executive functioning (working memory, inhibitory control) in threat contexts, and explore tDCS-related changes in neural activity (EEG).
Study objective
A combined tDCS-working memory intervention in healthy military personnel strengthens self-regulation under threat via effects on DLPFC-linked neural activity.
Study design
Pre-assessment; 3 tDCS-sessions with working memory training; post-assessment.
Intervention
transcranial direct currect stimulation (tDCS); working memory training.
Inclusion criteria
- 18-60 years of age
- Uncorrected normal hearing
- Provide written informed consent
Exclusion criteria
- Alcohol or drug dependence
- Use of illicit drugs or psychoactive medication within the past two weeks
- Having a current psychiatric diagnosis
- Having a current or previous neurological disorder.
- Serious head trauma or brain surgery
- Large or ferromagnetic metal parts in the head
- Implanted cardiac pacemaker or neurostimulator
- Pregnancy
- Concurrent or recent (within previous month) participation in a neuromodulation or neurostimulation (e.g., tDCS, TMS) experiment.
- Skin damage or diseases at intended electrode sites (tDCS)
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL8028 |
| Other | METC Utrecht : 19/452 |