No registrations found.
ID
Source
Brief title
Health condition
Migraine
Sponsors and support
Intervention
Outcome measures
Primary outcome
Percentage of change in dermal blood flow response to capsaicin application and saline iontophoresis after sumatriptan or placebo administration.
Secondary outcome
• Heat sensation after capsaicin application
• Blood pressure changes after sumatriptan use
Background summary
N/A
Study objective
Sumatriptan can block the increase in dermal blood flow (DBF) caused by application of capsaicin or electrical stimulation.
Study design
Start recruitment: 10-09-2013
Intervention
S.C. injection of sumatriptan
A.H. Meiracker, van den
's Gravendijkwal 230
Rotterdam 3015 CE
The Netherlands
+31-10-4639222
a.vandenmeiracker@erasmusmc.nl
A.H. Meiracker, van den
's Gravendijkwal 230
Rotterdam 3015 CE
The Netherlands
+31-10-4639222
a.vandenmeiracker@erasmusmc.nl
Inclusion criteria
• Age between 18 and 50 years
• Male or female
• Females should use an oral contraceptive pill
• Non-smoking for > 6 months
• Body mass index between 18 and 30 kg/m^2
• Capable and willing to give informed consent
• General good health, based on medical history and physical examination
Exclusion criteria
• History of cardiovascular disease
• Perimenopausal status of females
• Any serious illness that can compromise study participation
• Use of any medication (e.g., NSAIDs, other analgesics) < 48 hrs before the study
• Dermal diseases at the upper frontal side of the face
• Pregnancy or breastfeeding
• History of sensitivity to the fruits of capsicum plants (e.g. chilli peppers)
• Alcohol or drug abuse
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3999 |
| NTR-old | NTR4171 |
| Other | : Erasmus MC MEC-2012-326 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |