No registrations found.
ID
Source
Health condition
Androgens, ovaries, female-to-male transsexuals
Sponsors and support
Department of Obstetrics and Gynaecology in collaboration with the department of Gender Dysphoria of the VU University Medical Center.
Intervention
Outcome measures
Primary outcome
Ovarian morphology, in terms of:
- transvaginal ultrasound
- histopathological features
Secondary outcome
Predisposition towards hyperandrogenism and reproductive alterations in gender dysphoric (GD) individuals, and are polycystic ovaries more likely in GD females?
Background summary
Prospective observational cohort study.
The aim of this study is to examine the ovarian effects of long-term androgen treatment in gender dysphoric females. This will enable us to provide: 1. adequate care for FtMs concerning their inner genitalia, especially ovaries and 2. provide more insight in the pathophysiologic mechanism of PCOS. Standard androgenic treatment or surgery as part of their sex-reassigment hormonal therapy will not be influenced. Morphologic changes of ovaries will be determined by transvaginal ultrasound and histopathology.
Study objective
Long term androgen treatment in female-to-male transsexuals (FtMs) leads to changes in the ovaries: polycystic ovaries, determined by transvaginal ultrasound and histopathology.
So the aim of this study is to determine wether long-term high doses of exogenous androgens affect ovarian morphology. In terms of: 1. transvaginal ultrasound and 2. histopathological features.
Study design
T = 0: start androgenic treatment
T = 1: operation day (minimum of 12 months after start treatment)
Intervention
Standard androgenic treatment as part of their sex-reassignment hormonal therapy.
Afdeling Voortplantingsgeneeskunde (Gynaecologie en Obstetrie) <br>
VU Medisch Centrum <br>
Gebouw Zuid, F 16 <br>
Postbus 7057 <br>
1007 MB Amsterdam
M.R. Caanen
Amsterdam
The Netherlands
m.caanen@vumc.nl
Afdeling Voortplantingsgeneeskunde (Gynaecologie en Obstetrie) <br>
VU Medisch Centrum <br>
Gebouw Zuid, F 16 <br>
Postbus 7057 <br>
1007 MB Amsterdam
M.R. Caanen
Amsterdam
The Netherlands
m.caanen@vumc.nl
Inclusion criteria
- Diagnosis Gender Dysphoria
- >1 year cross-sex hormonal treatment
- Age 18+
- Intention to undergo sex-reassignment surgery
Exclusion criteria
- Disorder of sexual development
- Concomitant pathology with known or possible endocrine effects
- Excessive alcohol or drug abuses
- Patients who explicitly declare that they do not want to participate in the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4632 |
| NTR-old | NTR4784 |
| Other | METC VUmc : 2014.402 |