No registrations found.
ID
Source
Health condition
dopamine antagonism, noradrenaline antagonism, subjective probability processing, subjective value processing, dopamine antagonisme, noradrenaline antagonisme, subjectieve waardevolheid, subjectieve waarschijnlijkheid.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cue specific P200 event-related potential relative to no cue, cue specific P300 event-related potential relative to no cue. Independent variables: Subjective value, Subjective probability, dopaminergic antagonism by haloperidol and noradrenergic antagonism by clonidine.
Secondary outcome
- Velocity scaling measurement
- Spontaneous motor activity measurement
- Event related potentials in response to the target
- Reaction times in response to the target
- Target omissions and percentage correct responses
- Questionnaire scores (attentional control, State-trait anxiety inventory)
Study objective
We hypothesize that the brain dopamine system plays a role in subjective probability processing and we hypothesize that both the brain dopamine and noradrenaline system play a role in subjective value processing.
Study design
Participants will be tested during 3 separate sessions.
Measurements will be made 3 hours after capsule intake.
Intervention
- one capsule containing 150 microgram clonidine
- one capsule containing 2 milligram haloperidol
- one capsule containing placebo
Iris Schutte
Heidelberglaan 2
Utrecht 3584 CS
The Netherlands
+31 30 2534368
i.schutte@uu.nl
Iris Schutte
Heidelberglaan 2
Utrecht 3584 CS
The Netherlands
+31 30 2534368
i.schutte@uu.nl
Inclusion criteria
Male, non-smoking, age between 18-45 years and passing the screening (assessing medical history and blood pressure/heart rate)
Exclusion criteria
Psychopathology, current medication use, (history of) serious medical condition(s), low blood pressure, heart rate above 100 bpm or below 60 bpm in rest.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4917 |
| NTR-old | NTR5019 |
| CCMO | NL51144.041.14 |
| OMON | NL-OMON44020 |