No registrations found.
ID
Source
Brief title
Health condition
depression, memory problems, electroconvulsive therapy, pulsewidth
Sponsors and support
GGZ Delfland
GGZ Delfland
Intervention
Outcome measures
Primary outcome
Depression scores assessed by the Montgomery Ãsberg Depression Rating Scale (MADRS)
Secondary outcome
Memory score assessed by the Autobiographical Memory Interview (AMI)
Background summary
The most important adverse effect of ECT is the occurrence of retrograde amnesia. This is a major obstacle for the more widespread use of the most efficacious treatment of depression.
Studies suggest that clinicians can manipulate the efficacy and amnesic effects of ECT to a certain degree by using different ECT techniques. In general the most efficacious forms of ECT also show more serious amnesic effects. A comparison of several ECT techniques is useful to confirm the findings from previous studies in different clinical settings.
In this study patients are randomised in two groups. In group one patients receive treatment with unilateral, ultra-briefpulse (=pulsewidth 0.3 msec) ECT, in group two patients receive treatment with unilateral, briefpulse (=pulsewidth 1 msec) ECT. The antidepressive action is assessed using depression rating scales and adverse cognitive effects are assessed using a neuropsychological test battery. Assessments are done single-blind.
Study objective
Ultra-briefpulse (=pulsewidth 0.3 msec) ECT is equally efficacious as briefpulse (=pulsewidth 1 msec) ECT in its antidepressive action but causes less retrograde amnesia.
Study design
Depression score: baseline, weekly for six weeks, end point after six weeks
Memory score: baseline, three weeks, end point after six weeks
Intervention
Ultra-briefpulse ECT (=pulsewidth 0.3 msec) vs. briefpulse ECT (=pulsewidth 1 msec)
Psycho-Medisch Centrum
Prins Bernhardlaan 177
A. Vrijburg
[default] 2273 DP
The Netherlands
+31 (0)70 391 8666
Psycho-Medisch Centrum
Prins Bernhardlaan 177
A. Vrijburg
[default] 2273 DP
The Netherlands
+31 (0)70 391 8666
Inclusion criteria
1. 18 years or older
2. Major depression according to DSM IV criteria (APA, 1994) diagnosed with the (M.I.N.I.) Mini-international Neuropsychiatric Interview (Sheenan, Lecrubier, 1998)
3. Able to give informed consent
Exclusion criteria
1. History of alcohol or drugs abuse or dependence
2. History of head injury
3. Dementia according to CBO guidelines (NVKG, 2005)
4. Exclusion criteria according to the ECT-guidelines (NVvP, 2000)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1258 |
| NTR-old | NTR1304 |
| Other | Assigned by the METiGG : METiGG no.: 6232 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |