No registrations found.
ID
Source
Brief title
Health condition
Hematological patients
Sponsors and support
Intervention
Outcome measures
Primary outcome
Efficacy of platelet transfusion or red blood cell exchange transfusion in hemato-oncological patients and sickle cell patients, respectively, in relation to several endothelial activation markers.
Secondary outcome
n.a.
Background summary
20 patients with a hemato-oncological diagnosis and 20 patients with sickle cell disease will be asked to participate. After informed consent two blood samples will be drawn, before and after intervention (platelet transfusion and red blood cell exchange respectively). These samples will be used to test several known markers of endothelial cell activation/damage in a pilot study.
Study objective
Efficacy of transfusion support depends on disease and treatment related patient factors. Markers of endothelial damage have been identified, but till today not in relation to the efficacy of transfusions.
Intervention
None
Leyweg 275
J.L.H. Kerkhoffs
Den Haag 2545 CH
The Netherlands
+31 (0)70 3592004
J.Kerkhoffs@hagaziekenhuis.nl
Leyweg 275
J.L.H. Kerkhoffs
Den Haag 2545 CH
The Netherlands
+31 (0)70 3592004
J.Kerkhoffs@hagaziekenhuis.nl
Inclusion criteria
1. Age > 18 years;
2. Hemato-oncological disease;
3. Sickle cell disease;
4. Informed consent
Exclusion criteria
1. Active cardiovascular disease;
2. Recent thrombo-embolism.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL658 |
| NTR-old | NTR909 |
| Other | : N/A |
| ISRCTN | ISRCTN35472475 |