No registrations found.
ID
Source
Brief title
Health condition
FoBoMin
preterm infants
bone mineralization
length
Sponsors and support
Intervention
Outcome measures
Primary outcome
To determine whether increased calcium and phosphate intake (2005 group) resulted in improved Bone mineral content (BMC) and Bone mineral density (BMD) compared to the group with less calcium and phosphate intake (2004 group) at the age of 8-10 years, determined by DEXA-scan.
Secondary outcome
To determine whether increased perinatal calcium and phosphate intake (group 2005) compared to lower perinatal calcium and phosphate intake (group 2004) at the age of 8-10 years results in:
- improved BTT (bone-transit time= speed of sound (m/sec)) determined with QUS.
- improved length, weight, head circumference
Study objective
Preterm infants have a reduced length and bone density in later life compared to peers born at term.
In our study we want to determine if preterm infants with different intake of calcium and phosphate in the neonatal period, have a difference in bone mineralization and length at the age of 8-10 years.
We hypothesize that the former preterm infants, with higher intake of calcium and phosphate have an improved bone mineralization and length compared to the preterm infants with less intake of calcium and phosphate.
Study design
just one outpatient visit
Intervention
- Questionnaire
- Anthropometric measurements
- Quantitative ultrasound
- DEXA-scan
Postbus 9101
M.E. Putten, van der
Nijmegen 6500 HB
The Netherlands
+31 24 3614430
Mayke.vanderPutten@radboudumc.nl
Postbus 9101
M.E. Putten, van der
Nijmegen 6500 HB
The Netherlands
+31 24 3614430
Mayke.vanderPutten@radboudumc.nl
Inclusion criteria
The children who were included in a former cohort study were born during the year 2004 (68 children with the old composition of parenteral feeding) and 2005 (79 children with the new composition of parenteral feeding). They had at birth a gestational aged below 34 weeks, were admitted to our NICU of the first day of life and had an expected duration of parenteral nutrition of more than five days.
Of these former cohorts 55 respectively 60 children were seen at the follow-up at two years and these children we have invited for the current FoBoMin study.
Exclusion criteria
- Asphyxia
- Congenital malformation
- Renal or hepatic insufficiency at birth
- No follow up at 2 years of age
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4413 |
| NTR-old | NTR4842 |
| Other | METC : 2013/594 |